Patent Watch

This article briefly summarizes novel aspects of selected United States (U.S.) patents involving controlled release or delivery that were issued from July 1 to December 31, 2015. Greater detail on each can be found on the U.S. patent website at http://patft.uspto.gov/.

U.S. patent 9,221,893 – Preparation and use of hyaluronic acid-protein conjugates for controlled delivery of treatment to the liver and past the liver are disclosed.

U.S. patent 9,220,689 – Nano-sized cationic acrylic copolymer particles are used as templates for deposition of a silica shell to create core-shell nanoparticles for controlled delivery of payload in response to pH.

U.S. patent 9,216,198 – Electrospun fibers containing nitric oxide releasing materials or particles are described for controlled release of nitric oxide.

U.S. patent 9,212,259 – Polymers that are liquid at room temperature and gel at physiological pH/temperature are used for controlled release of nitric oxide from implants.

U.S. patent 9,089,830 – Incorporation of a volatile burst aid into interfacially polymerized microcapsules enables temperature triggered burst release in relation to the vapor pressure of the volatile component.

U.S. patent 9,212,335 – A mixture of a diamine and perfuming aldehydes and/or ketones in the presence of water provides an extended release profile for the perfuming ingredients.

U.S. patents 9,198,877 and 9,205,062 – Multiple adhesive layers with varying drug release properties are used to control drug delivery through the skin.

U.S. patent 9,205,051 – Porous sustained release silicon implants with drug fully dispersed throughout the structures are disclosed.

U.S. patent 9,199,035 – Electrochemically driven pumps that employ an electrochemically active gas to displace and deliver fixed amounts of drug at appropriate times to locations such as the eye are disclosed.

U.S. patent 9,132,231 – A wearable chambered controlled drug delivery device consisting of a gas generator to incrementally deliver drug is described.

U.S. patent 9,204,632 – Controlled release microcapsules of pesticides, herbicides, and the like are produced by in situ polymerization of a polyurethane shell.

U.S. patent 9,156,745 – Robust controlled release fertilizers consisting of a fertilizer core and a polyurethane coating with an organic carbonate additive are described.

U.S. patent 9,120,709 – Polymer layering is used to create a controlled release urea fertilizer.

U.S. patent 9,198,875 – A polymeric cyclodextrin host is used in layered decomposable polyelectrolyte films for controlled release of hydrophobic bioactive materials.

U.S. patent 9,186,640 – Coacervates consisting of a lipophilic core such as fish oil and shell formed from cationic and anionic polymers are described.

U.S. patent 9,155,703 – This invention involves the formation of a molecular bond to alter the structural integrity of a polymeric network and control release of active agents.

U.S. patents 9,114,176 and 9,095,623 – Drug is incorporated in a conjugate framework with affinity ligands and multivalent cross- linking agents that bind with exogenous target molecules. Competition between the exogenous target molecules and affinity ligands for binding with the cross-linking agents triggers release of the drug.

U.S. patent 9,198,840 – An encapsulated evaporative cooling agent is applied over color cosmetics to control the rate of water/volatile component loss and extend the functional time of the cosmetic.

U.S. patent 9,149,426 – Biocompatible, biodegradable nanoparticle systems composed of drug and poly(ortho ester) polymers for zero order delivery are disclosed.

U.S. patent 9,186,351 – A dosage form consisting of a pH lowering agent and a gel-forming polymer creates a pH stable environment to extend melatonin release into the intestinal region.

U.S. patent 9,173,949 – High-molecular-weight dendritic polymers with biodegradable spacers are employed for targeted drug delivery to tumors.

U.S. patents 9,155,311 and 9,078,445 – Aluminum phosphate containing bioactive molecules are dispersed within a polymer to control antimicrobial resistance upon exposure to water.

U.S. patent 9,138,417 – Interfacial polymerization of a vinyl monomer is used to create controlled release particles of an antibiotic.

U.S. patent 9,125,807 – In situ formation of a hydrogel is used for controlled delivery of a therapeutic agent to the eye.

U.S. patent 9,114,187 – A printable identification wristband with a controlled release antimicrobial coating is disclosed.

U.S. patent 9,119,793 – Floatable, swellable, and bioadhesive gastroretentive formulations of doxycycline are described for maximum therapeutic efficacy of doxycycline.

U.S. patent 9,119,780 – An ester of a functional active is used for controlled delivery of the active by hydrolysis.