Patent Watch
This article summarizes selected patents in the area of controlled release or delivery that were issued from Feb 21, 2023 through May 30, 2023. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 11655373- Method of Preparing Electric and Temperature Dual-control Bi-stable Color-changing Dyes And Microcapsules
A method of preparing electric and temperature dual-control color-changing dyes and microcapsules. When being driven by voltage and temperature, the microcapsules achieve controllable color change performance.
US- 11649392- Application of Polyelectrolyte Complex Nanoparticles to Fluid Loss Control of Oil Well Cementing
A variety of fluid loss control compositions containing nanoparticles and methods are provided for a cementing operation. The polyelectrolyte complex nanoparticles can contain additional additives such as metal ions or fluid loss additives such as a cellulose polymer.
US- 11648512- Enhanced Emulsion Liquid Membranes for Extraction Of Pollutants From Water
Description of emulsion liquid membranes useful for extracting pollutants from industrial wastewater and water. The emulsion liquid membranes include, in various phases, at least one or a combination of nanoparticles and an ionic liquid.
US- 11633725- Composite Material, Its Manufacturing, Generation and Use in Methane Cracking
Description of nanoparticles made of transition metals for use as a catalyst surface in methane cracking.
US- 11628408- Bilayer Electrospun Membranes for Treating Fracking Wastewater Via Membrane Distillation
A bilayer electrospun membrane with nanoparticles for treating hydraulic fracking wastewater.
US- 11629282- Salt-tolerant Polymer Microsphere Plugging Agent and Preparation Method Thereof
A polymer microsphere plugging agent which improves the problem of low interfacial tension and poor salt tolerance in existing polymer microspheres.
US- 11612870- Microencapsulation of Chemicals and Bioactives by In Situ Complex Coacervation During Spray Drying
An industrially scalable microcapsule, fiber or film forming process and formulations suitable for use in conventional spray drying systems are provided. By using two polymers with different isoelectric points and a volatile acid or base while spray drying, the pH of the solution changes allowing for complexation of the two polymers.
US- 11613668- One-component Waterborne Self-healing Epoxy Formulation
Embodiments provide a self-healing coating formulation comprised of a one component waterborne epoxy-amine adduct resin system and a microencapsulated healing agent.
US- 11589578- Painting with Biocides Composition And/or Prolonged Release Pesticides
This invention refers to a paint composition with prolonged release biocides in microparticles made by interfacial polymerization and/or ionic gelation process.
US- 11583924- Synthesis of Nano Particles
The method includes dispersing metal oxide powder in a mixture of a base liquid and a surfactant to form a primary mixture and grinding the mixture using a grinding media until the desired particle size of is achieved.
US- 11584880 - Autonomous Extremophiles for Downhole Oil and Gas Applications Controlled By Metal Silica Nanoparticles
This patent describes the use of extremophilic bacteria that has signal transduction chemotaxis machinery combined in a nano emulsion with metal-silica nanoparticles for enhanced oil recovery.
Agriculture
US- 11649195- Smart Release Nitrogen-containing Fertilizer Granules
A formulation of a microcapsule with a core of nitrogen-containing fertilizer surrounded by a functional layer containing an enzyme inhibitor, microbial suppressor, phosphorus solubilizer and potentially a plant hormone. A controlled release layer around the functional layer contains water-swellable nanoparticles. A final outer layer provides anticaking.
US- 11607424- Carbon-rich Micro-particles For Protecting Bees and Overcoming Colony Collapse Disorder
Compositions and methods for protecting bees from toxins and for preventing or decreasing colony collapse which comprise carbon microparticles which, when ingested by bees, increase their survival after exposure to toxins such as pesticides.
US- 11589577- Nanotechnology System for Agricultural Applications
A nanoparticle formulation containing an agrochemical active ingredient. In some cases, the nanoparticles are viral particles or capsids, particularly plant viral particles or capsids, or the carrier comprises an inert or biodegradable carrier to which the nanoparticles are bound or in which the nanoparticles are suspended.
US- 11591605-Plant Genome Editing Method
A method for editing a plant genome includes coating a microparticle with at least one type of nucleic acid and/or at least one type of protein, introducing a change into a target site in the genome of a plant by bombarding a shoot apex with the coated microparticle using a gene gun prior to growth of the plant.
US- 11591275-Smart Release Potash Fertilizer Granules
A formulation of a microcapsule with a potash core surrounded by an extended-release layer containing water-swellable nanoparticles and a water-soluble organic acid. A final anticaking layer is also incorporated.
Diagnostic/Sensing
US- 11639896 - Size Controllable Conjugated Polymer Nanoparticles with Fluorescence In The Spectral Range Between Far-red And Short-wavelength Infrared
Described are conjugated polymer nanoparticles with a maximum emission of light that occurs within a tissue transparent window of the electromagnetic spectrum and their use as fluorescent probes in biological imaging.
US- 11662350- Method and Kit for Detection Of Anti-Zika Virus Antibodies
A microsphere formulation coated with antigenic peptides from the Zika virus. The particles are exposed to a sample suspected of having anti-zika antibodies. The bound antibodies are detected by incubation with an anti-ZIKV detecting reagent.
US- 11662318- Methods to Detect Trace Levels Of Genetic Materials Using Colloidal Gold Nanoparticles On Quartz Paper Or Metamaterial Substrates And Surface-enhanced Raman Scattering
The use of colloidal gold nanoparticles deposited on quartz paper or metamaterial substrates to enable trace level detection of biological materials using Surface-enhanced Raman Scattering (SERS).
US- 11654204- Rod-shaped Plant Virus Nanoparticles as Imaging Agent Platforms
Description of use of a rod-shaped plant virus linked to an imaging agent. The viral particles can be further formulated into spherical nanoparticles and used for imaging of specific tissues.
US- 11649173- Continuous Synthesis of Upconverting Nanoparticles
Method to continuously synthesize core-shell upconverting nanoparticles.
US- 11634507- Dendritic Gold Nanoparticles and Methods of Synthesis
A method of producing dendritic gold nanoparticles which may be used to deliver therapeutic, diagnostic, and/or immunogenic molecules.
US- 11624746- Test Strip for Milk Immunofluorescence Assay (IFA) And Use Thereof
Describes the structure and use of fluorescent latex microspheres labeled with antibodies. The microspheres are mounted within a test strip to quantitively detect casein, BLG, ALA, and lactoferrin/BSA in food.
US- 11617804- Hyaluronic Acid-based Nanoparticles as Biosensors For Imaging-guided Surgery And Drug Delivery Vehicles And Methods Associated Therewith
Description of nanoparticles incorporated with hyaluronic acid for imaging and drug delivery in cancer treatment applications.
US- 11596697- Nanoparticle Conjugates
Conjugates comprising a drug, cell or biological molecule bound to a photoluminescent polymer nanoparticle, as well as their methods of manufacture and their uses in biological imaging and sensing applications.
US- 11598779- Detection of Cancer Biomarkers Using Nanoparticles
Description of use of nanoparticles that bind specific biomarkers to distinguish between a healthy and diseased state.
US- 11596876- Channeled Fibers in Separation of Biologically Active Nanoparticles
Use of channeled fibers in hydrophobic interaction chromatography to isolate biologically active nanoparticles either natural or synthetic.
US- 11598777- Immuno-optomagnetic Point-of-care Assay and Method For Detection Of Analyte Using Multifunctional Optomagnetic Quantum Dot Nanocrystals (MQDs)
A method for making and using magnetic nanoparticles or quantum dots conjugated with antibodies for quantifying an analyte.
US- 11591648- Nanochannel with Magnetic Sensor for The Detection of Molecules
Method of utilizing a nanochannel in combination with at least one magnetic sensor for detecting molecules, cells, and other analytes labeled with magnetic nanoparticles. The method is particularly suited for identifying nucleotides of DNA and RNA strands.
Pharma
US- 11660349- Non-linear Multiblock Copolymer-drug Conjugates for The Delivery Of Active Agents
Non-linear multiblock copolymer-drug conjugates that can be formulated as nano or microparticles or implants for the treatment and prevention of diseases and disorders of the eye.
US- 11660270- Nanoparticle Compositions
Description of generating and using various nanoparticle formulations for nasal administration upon atomization. The particles are comprised of lipids or polyanhydrides.
US- 11660339- Methods of Treating Cancer Using Compositions of Antibodies And Carrier Proteins With Antibody Pretreatment
Described herein are methods, formulations, and kits for treating a patient with cancer with anti-VEGF antibodies and albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes.
US- 11654200- Compositions and Methods for Delivery Of RNA
A nano emulsion composition of inorganic nanoparticles in a lipid nanoparticle that can be used for imaging and delivery of nucleic acids.
US- 11654117- Melt Processed Viral Nanoparticle Constructs
A melt process formulation for delivery of virus or virus-like particles to a site of interest.
US- 11642320- Nanoparticulate Prodrugs
An anti-inflammatory drug formulation consisting of a corticosteroid prodrug nanoparticle.
US- 11642419- Compositions and Methods for Treating Cardiovascular Related Disorders
Description of making and using synthetic HDL carriers for treating cardiovascular disorders. Applications in imaging or targeted delivery are also outlined.
US- 11639329- Lipids for Use in Lipid Nanoparticle Formulations
A formulation of lipid nanoparticles for delivery of therapeutic agents.
US- 11638741- Composition for Treating Cancer or Inhibiting Cancer Metastasis, Including TFG Or TFMG Nanoparticles
A formulation of TFG or TFMG nanoparticles for treatment of cancer through normalizing blood vessels within a tumor.
US- 11638754- HPV Vaccine
A pharmaceutical composition that includes a lipid nanoparticle adjuvant and an HPV virus-like particle (VLP).
US- 11633485- Cleavable Esters for Nanocarrier-based Cancer Therapy
A nanoparticle formulation containing a co-drug with anticancer or anti-restenotic activities for treatment of cancer.
US- 11633360- Method for Preparing Biodegradable Microspheres Using Stabilized Single-phase Mixed Solution
Description of a method to generate microspheres using a single-phased solution of water, alcohol, and dichloromethane. This method does not employ surfactants or thickeners to maintain a single-phase during particle generation.
US- 11633365- Nucleic Acid-containing Lipid Nanoparticle
A nucleic acid-containing lipid nanoparticle comprising an analog of a fatty acid ester of glycerol, and a nucleic acid, wherein the analog is not hydrolysable by a lipase.
US- 11633363- Fusion Proteins Having a Toxin and Cancer Marker, Nanoparticles, And Uses Related Thereto
This disclosure relates to nanoparticles coated with fusion proteins comprising a domain that binds a cancer marker and a domain comprising a toxic polypeptide.
US- 11628227- Mineral Coated Microparticles for Gene Delivery In Chronic Wound Therapy
Disclosed are formulations for providing a therapeutic bioactive polypeptide to injured tissue. Formulations include mineral coated microparticles wherein a polynucleotide is adsorbed to the mineral layer. Also disclosed are methods for sustained delivery of a bioactive polypeptide.
US- 11628208- System and Method for Microneedle Delivery Of Microencapsulated Vaccine And Bioactive Proteins
Description of using micro or nanoparticles containing a vaccine and incorporating those particles into a microneedle array for transdermal delivery.
US- 11622937- Polyphenolic Polymer to Make Water-insoluble Molecules Become Water-soluble
A method of production and use of a nanoparticle formulation made up of a polyphenolic polymer for encapsulation of poorly water-soluble actives. The polyphenol encapsulation material also imparts antioxidant, antimicrobial, anti-inflammatory properties while also increasing bioavailability of actives such as artemisinin, aspirin and pyrethrin.
US- 11622942- Benzene-1,3,5-tricarboxamide Derived Ester Lipids and Uses Thereof
The present disclosure relates to benzene-1,3,5-tricarboxamide derived ester lipid compounds, compositions, lipid-like nanoparticles, and methods using the lipid for delivery of therapeutic, diagnostic, or prophylactic agents.
US- 11617800- Nanoparticle-enhanced Activity of A Potassium Channel-blocking Peptide
A nanoparticle (NP)-peptide conjugate provides efficient steric hindrance/blockage of cellular membrane potassium channels to mediate membrane depolarization.
US- 11617723- Composition for Hepatic Arterial Chemoembolization Using Human Serum Albumin Nanoparticles Carrying Anticancer Agent, And Method for Producing Same
Use of albumin nanoparticles to carry and continuously release Adriamycin for hepatic arterial chemoembolization.
US- 11617720- Main Agent Uniformly Dispersed Microsphere and A Sustained Release Formulation Comprising the Same
A microparticle formulation in size from 1 to 150 microns with evenly distributed active throughout the particles resulting in controlled release.
US- 11618901- Anti-miRNA Carrier Conjugated with A Peptide Binding to A Cancer Cell Surface Protein and Use Thereof
A cancer treatment using porous silica nanoparticles loaded with anti-miRNA to which a cancer cell surface protein-binding peptide is conjugated.
US- 11607391- Mineral-coated Microspheres
Method of generation and administration of a microsphere bead coated with a calcium-containing mineral.
US- 11607467- Synthesis of Nanoparticle in Liquid, Semi-solid Media And In Cells And Tissues Using Cold Plasma Technology
A method of forming metal nanoparticles from a substance using cold plasma in an area of interest, wherein the substance is a solution that contains metal ions, and the nanoparticles synthesized are metallic in nature.
US- 11607392- Encapsulation System for Prolonged Release of Active Agents
The present technology generally relates to a matrix of microcapsules encapsulation system for delivery of an active agent. Capsules of various sizes (0.1-10 microns, 10-100 microns, and a third population 100-500 microns) are combined to tailor the release of the active.
US- 11603544- Genomic Safe Harbors for Genetic Therapies in Human Stem Cells and Engineered Nanoparticles To Provide Targeted Genetic Therapies
Genomic safe harbors (GSH) for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies are described. The GSH and/or associated nanoparticles can be used to treat a variety of genetic, infectious, and malignant diseases safely and efficiently.
US- 11603543- Fusogenic Lipid Nanoparticles for Target Cell-specific Production of A Therapeutic Protein
Use of lipid nanoparticles containing nucleic acid constructs for cell-specific production of a therapeutic protein for senescent or cancer cells is described.
US- 11602509- Salt of Cysteamine for The Preparation of Highly Respirable Particles
Preparation and pharmaceutical composition of an inhalable microparticle formulation having cysteamine hyaluronate salt is provided.
US- 11602532- Nanoparticle Formulations of Decoquinate in The Form Of Solid Solution
A hot-melt extrusion method used to produce nanoparticles containing decoquinate. The nanoparticle formulation results in higher suspension stability and enhanced bioavailability and efficacy against malaria.
US- 11590078- Viral Immunogenic Compositions
A formulation of a polynucleotide and antigen(s) in a nanoparticle or liposome is described along with methods of inducing protective or therapeutic immune responses by administration of one or more of these immunogenic compositions.
US- 11590241- Nanoparticle Conjugated Synthetic Opioid Prodrugs and Methods of Their Uses
Presentation of a nanoparticle conjugated synthetic opioid prodrug formulation. The prodrug has advantages such as long bioavailability, while not compromising the analgesic effects of opioids administered for pain relief and does not induce opioid withdrawal when discontinued.
US- 11590098- Methods of Treating Triple-negative Breast Cancer Using Compositions of Antibodies And Carrier Proteins
Methods and formulations for treating triple-negative breast cancer with nanoparticle complexes comprising a carrier protein (e.g., albumin), paclitaxel and a target antigen expressed by the cells (e.g., an anti-VEGF antibody).
US- 11590084- Microcapsules for Controlled Delivery of An Active Pharmaceutical Ingredient
The present invention relates to a microcapsule made by modified interfacial condensation polymerization. The shell of the capsule contains moieties that can easily be functionalized.
US- 11591544- Ionizable Cationic Lipids
Provides compounds useful as ionizable cationic lipids for use in nanoparticle formulations involving therapeutic nucleic acids to cells. The lipids were engineered with improved oxidation and degradation properties.
US- 11583585- Gold Nanoparticles and Ecological Method of Production
A method of preparing gold nanoparticles by mixing at least one flavonoid-rich plant extract (Hubertia ambavilla or Hypericum lanceolatum) with an aqueous solution of a gold salt.
US- 11583613- Hydrogel Systems for Skeletal Interfacial Tissue Regeneration Applied to Epiphyseal Growth Plate Repair
Describes the use of microparticles with hydrogel carriers, growth factors, chondrogenic and immunomodulatory cytokines for regeneration of epiphyseal growth plate or other interfacial tissue structures.
US- 11583504- Stabilized Formulations of Lipid Nanoparticles
The disclosure features a lipid nanoparticle (LNP) and a stabilizing agent that mitigates the degradation of the LNPs. Examples of use include therapeutics and/or prophylactics such as RNA delivered to mammalian cells or organs.
US- 11583503- Composition for Promoting Wound Healing and Preparing Method Thereof
A method of making and using microspheres of a hydrophobic polymer and surfactant containing sodium hydrogen sulfide for sustained release in promoting wound healing.
Bio
US- 11648374- Surface Topography with Ferromagnetic Polymer Pillars Capable of Movement In Response To Magnetic Fields
Describes the use of iron oxide nanoparticles in micron-scale pillars on a surface that can be moved in a magnetic field to mimic cilia to inhibit surface fouling and biofilm formation.
US- 11643335- Method of Making Chromium-substituted Spinel Ferrite Nanoparticles For Microbe Treatment
Methods of forming spinel ferrite nanoparticles containing a chromium-substituted copper ferrite. Methods of preventing or reducing microbe growth on a surface by applying these nanoparticles are also described.
US- 11612676- Tissue-derived Scaffolding Materials and Method For Tissue Formation
Platform scaffolding formulations in the forms of hydrogel, sponge, fibers, microspheres, and films made up of homogenized tissue-derived suspension in a polymeric solution of synthetic or natural polymers are presented. Uses such as 3D tissue models of various tissue types are described.
US- 11596585- Composition for The Prevention Of Microbial Growth
A composition for reducing microbial activity in an environment susceptible to microbial activity, comprising metallic nanoparticles; and an oxygenation agent.
Consumer Products/ Cosmetics
US- 11661569- Liquid Detergent Composition Comprising Suspended Solid Particles
A liquid detergent formulation that contains solid particles dispersed in a continuous phase is described along with its intended use.
US- 11654119- Bioavailable Curcumin Nanoparticles and Methods of Making
Formation of low-crystallinity curcumin nanoparticles via controlled supercritical carbon dioxide impregnation of curcumin into biodegradable nano porous starch aerogels is disclosed and use in nutraceutical foods is described.
US- 11654410- Method for Preparing Biodegradable Microcapsules and Microcapsules Thus Obtained
A method of making microcapsules containing essential oils using a form of interfacial polymerization.
US- 11648195- Cosmetic Composition for Improving Skin Condition Containing Peony Extract as Active Ingredient for Heat Shock Protein Activation
The present invention relates to a cosmetic composition which includes microcapsule particles stabilized by encapsulating a peony extract with a bio copolymer, and a fibrous protein surrounding the particles in a matrix form for improving skin condition.
US- 11648522- Polyurea Capsules Cross-linked with Chitosan
An improved process of forming polyurea and chitosan microcapsules encapsulating a benefit agent is described.
US- 11642552- Warming Composition and Aerosol Formulation Including Same
Describes the use of zeolite nanoparticles in an aerosolized formulation applied to a surface. Warming is achieved by the hydration of the zeolite in the presence of water on/in the skin.
US- 11642290- Non-spherical Microcapsule
Disclosed is a non-spherical microcapsule with a core of a fatty ester and a benefit agent and a shell of nanoparticles for use in personal care, textiles, hard surfaces, hair, and skin.
US- 11642316- Water-soluble Curcumin Mixture with High Bioavailability and Preparation Method And Application Thereof
A formulation with application in the food industry involves combining curcumin with vitamin C and ascorbyl palmitate into a co-crystal. The co-crystal is then encapsulated to improve aqueous dispersion.
US- 11622928- Organic Compounds
Disclosed is a composition comprising at least one core-shell microcapsule in a suspending medium. The shell comprises a hyperbranched polysaccharide.
US- 11597834-Polymer Microparticle for Filler, Manufacturing Method Thereof, Freeze-dried Body Including the Same, And Filler Injection Including The Same
A formulation used as a filler made up of aggregated and overcoated particles (a “raspberry-shaped structure”). A lyophilized version and filler injection version are also described.
US- 11590258- Vitamin C-containing Polycaprolactone Microsphere Filler and Preparation Method Therefor
A polycaprolactone microsphere containing vitamin C, a filler including the same and a preparation method is given. When injected into a living body, the formulation exhibits a rapid collagen formation effect as well as a high tissue restoration property.
Observations/Thoughts/Trends/Musings
The online patent database I use to draft these summaries has had a long-overdue update. The interface seems to be much more user-friendly for advanced searches and I seem to be getting more hits using the same search parameters I used previously. While I only search the US-PAT database for patents that have been issued, there are other databases available for searching beyond issued patents (patents submitted but not yet issued for example). If you haven’t ever used the search function on the site referenced at the beginning of this document, I recommend it for learning the “hot” areas of research and development or just general knowledge.
Before the next quarterly patent review is released, we will have had our annual meeting in Las Vegas. I hope you will come by our booth in the expo hall (Southwest Research Institute)!
Ken
