Patent Watch: January - February 2024
This article summarizes selected patents in the area of controlled release or delivery that were issued from January 1, 2024 through February 27, 2024. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 11913930- Bismuth Oxide Based Ammonia Sensor
Describes the use of 1-3 um diameter bismuth oxide microparticles for gas low-concentration ammonia detection.
US- 11905389- Molecularly Self-assembling Nanocomposite Barrier Coating For Gas Barrier Application And Flame Retardancy
Disclosed is a transparent self-assembling polymer clay nanocomposite coating that is useful in food, drink and electronic packaging as a gas barrier and on textiles and clothing as a flame retardant coating made up of a water-dispersible polymer and a nanoparticle/platelet.
US- 11904296- Water extractable Microcapsules Of Activated Carbon, Super Activated Carbon, And Other Adsorptive And Reactive Materials
A description of a system using a microcapsule with a particle core of either activated carbon, super activated carbon, MOF composition, multifunctional material or a mixture and a water-soluble polymer shell, to be embedded in clothing for chemical warfare protection.
US- 11896966- Antibacterial Material And Antibacterial Film And Antibacterial Member Using The Same
An antibacterial material using microparticles containing tungsten oxide. The microparticles have an antibacterial activity against several pathogenic bacteria when stored with a test piece for 24 hours.
US- 11891458- Starch-containing Microsphere And Preparation Method And Use Thereof
A preparation method of starch-containing microspheres using starch and epichlorohydrin reacted in the presence of a surfactant. The microspheres are polydisperse starch-containing microspheres with a uniform particle size distribution from 0.1-500 μm.
US- 11857954- Supported Nanoparticle Compositions And Precursors, Processes For Making The Same And Syngas Conversion Processes
Nanoparticle compositions, used in catalyst preparations for converting syngas via the Fischer-Tropsch reactions to make olefins and/or alcohols.
US- 11884539- Systems And Methods For Manufacturing Nano-scale Materials
Methods and systems for high-speed production of nanoparticles with very high product yields using concentric micro-scale capillaries. The system can include on-line analytical tools for real time characterization of products or intermediates. The system includes a print head and a print bed and provides for random or patterned deposition of nanoparticles.
US- 11878914- High-throughput Synthesis Of Metallic Nanoparticles
This invention relates to cost-effective methods for synthesizing metallic nanoparticles in high yield using non-dendrimeric branched polymeric templates, such as branched polyethyleneimine.
US- 11879091- Reservoir Emplacement of Rheologically Tuned And Timed Nanoparticle Emulsions
Methods are disclosed for emplacing a gel-form material composed of nanoparticles, gelation components and surfactants in a porous subterranean formation, such as a hydrocarbon reservoir. The composition of the mixture is tuned for the required rheological properties.
US- 11878280- Microcapsules Comprising Natural Materials
A method is disclosed for preparing controlled release particulate formulations made up of a hydrophobic active an isocyanate, an epoxy, an organofunctional silane, and optionally a pre-reacted natural material resin, and plasticizer. By combining with an amine moiety, heating, and adding a natural material with hydroxyl groups with an aldehyde and the mixture in an emulsion, microparticles are formed.
US- 11873236- Date Palm Frond Modified Cellulose Extracts Hydrogel-encased With Metal Oxides Nanohybrids For Wastewater Treatment
A carboxymethyl cellulose (CMC) composition comprising CMC loaded with metal nanoparticles, such as silver nanoparticles (AgNPs), iron nanoparticles (FeNPs), or silver nanoparticle-doped iron nanoparticles (AgNPs@FeNPs) for removal of contaminants, such as 2,4-dinitrophenol, from wastewater
US- 11866332- Carbon Nanoparticle-porous Skeleton Composite Material, Its Composite With Lithium Metal, And Their Preparation Methods And Use
Carbon nanoparticle-porous skeleton composite material, its composite with lithium metal, and their preparation methods and use A carbon nanoparticle-porous skeleton composite material, its composite with lithium metal, and their preparation methods and use. In the carbon nanoparticle-porous skeleton composite material, the porous skeleton is a carbon-based porous microsphere material with a diameter of 1 to 100 μm or a porous metal material having internal pores with a micrometer-scale pore size distribution, and the carbon nanoparticles are distributed in pores and on the surface of the carbon-based porous microsphere material or the porous metal material. The carbon nanoparticle-porous skeleton composite material is mixed with a molten lithium metal to form a lithium-carbon nanoparticle-porous skeleton composite material. The carbon nanoparticles present in the material can better conduct lithium ions during the battery cycle, thereby inhibiting the formation of lithium dendrites, and improving the safety and cycle stability of the battery.
US- 11867039- Alternating Microsphere And Smartwater Injection For Enhanced Oil Recovery
A method for enhanced oil recovery in a reservoir is provided. The method includes injecting a microsphere suspension, including polymeric microspheres dispersed in seawater, into an injection well in the reservoir and injecting a low salinity tailored water (SmartWater) into the injection well in the reservoir. Oil is produced from a production well in the reservoir.
Agriculture
No patents found in this application area over the time frame explored.
Diagnostic/Sensing
US- 11904029- Particles Functionalized With Imageable Radioisotopes And Methods Of Making And Use Thereof
Description of use of radioisotopic microspheres used in imaging and/or to act as surrogate particles to predict distribution of therapeutic microspheres.
US- 11898952- Microparticle Measuring Apparatus and Microparticle Measuring Method
A device to measure microparticles flowing through a fluidic channel using light emission and method to use the device.
Pharma
US- 11911485- Ionizable Lipid Compounds, Lipid Nanoparticles Comprising Same And Therapeutic Uses Thereof
Lipid nanoparticles for in vivo drug delivery that are liver tissue-specific, have excellent biocompatibility and can deliver a gene therapeutic agent.
US- 11911481- Compositions and Methods For Treating RSV-infections
This invention provides for an RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as an anti-RSV prophylaxis and/or therapy.
US- 11911453- RSV RNA Vaccines
Respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines formulated in a lipid nanoparticle.
US- 11905525- Reduction Of Elimination Of Immune Responses To Non-intravenous, E.g., Subcutaneously Administered Therapeutic Proteins
Lipid nanoparticle formulations, and methods of use for delivering nucleic acids in vivo. These compositions have reduced immune activation and an improved toxicity profile and therapeutic index in vivo.
US- 11904022- Carrier-free Curcumin Nanoparticle For EGFR Positive Cancer Therapy
A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib.
US- 11904019- Bilirubin Nanoparticle, Use Thereof, And Preparation Method Therefor
A bilirubin nanoparticle formed by the self-assembly of bilirubin and a composite comprising a hydrophilic polymer is described. The nanoparticle exhibits antioxidant, antiangiogenic, anticancer, and anti-inflammatory activities.
US- 11896677- Compositions And Methods For Delivery Of RNA
Description of a method to generate lipid nanoparticles that deliver a bioactive agent such as a nucleic acid as well as imaging of the particle distribution after delivery.
US- 11896662- Multivalent Influenza Nanoparticle Vaccines
Disclosed herein are multivalent nanoparticle formulations for use in influenza vaccines using influenza glycoproteins as protective antigens. Methods of administering the nanoparticle vaccine compositions to a subject are also disclosed.
US- 11896037- Microencapsulation Of Active Agents
A description of a taste masking agent using a microsphere comprising a sweetener is given.
US- 11859201- Nanoparticle Compositions Containing Sugar Functionalized Nucleic Acid Carriers
Nanoparticle compositions for delivery of nucleic acids to subjects including carriers comprising sugar functionalized nucleic acid carriers, and therapeutic or immunogenic nucleic acid agents enclosed within the delivery molecules are described.
US- 11890370- Ultrasound-induced Drug Delivery System Using Drug Carrier Comprising Nanobubbles and Drug
An ultrasound-induced drug delivery system using a drug carrier containing a plurality of nanobubbles and a high concentration of a drug in one microcapsule. The nanobubbles collapse or aggregate when the ultrasound is applied to the drug delivery system resulting in active release. Due to the nanobubbles, the system can also be used as a contrast agent.
US- 11890332- Dual-scale Porous Silica Particle-based Composition For Preventing Or Treating Cancer
The present invention relates to a dual-scale porous silica particle-based pharmaceutical composition for preventing or treating cancer. The formulation elicits antigen-specific, cytotoxic T cells and exhibits increased anti-tumor efficacy compared with a mesoporous silica microrod (MSR) vaccine.
US- 11883541- Dual-scale Porous Silica Particle-based Composition For Preventing Or Treating Cancer
A formulation and method for administering a nanoparticle or microparticle and a therapeutic agent to the suprachoroidal space in the eye.
US- 11883536- Polylactic Acid Microsphere, Polylactic-co-glycolic Acid Microsphere And Method Of Preparing The Same
A method of preparing PLA and PLGA microspheres by solvent extraction/precipitation.
US- 11879126- MRNA Treatment Nanoparticles
Description of production and use of nanoparticles containing mRNA for cancer treatment is given.
US- 11873508- Thermoresponsive Microcarrier System and Uses Thereof
A NIPAM microsphere coated with polymerized catecholamines (e.g. DOPA). For culturing, harvesting and expanding stem cells.
US- 11872280- RNA Vaccine Against SARS-CoV-2 Variants
Description of a lipid nanoparticle for vaccination against coronavirus containing a nucleic acid active.
US- 11865225- Sustained Release Injectable Formulation Containing A Poly L Lactic Acid Filler And A Hyaluronic Acid Filler Conjugate And A Method For Preparing The Same
Disclosed is a sustained-release injection formulation containing a biodegradable microcapsule that contains a conjugate of poly-L-lactic acid filler and hyaluronic acid that can control the release rate of PLLA.
US- 11865158- Process And Composition Matter Of Nanoparticle Formulation For Systemic Treatment Of Sepsis
Nanoparticle formulation for systemic treatment of sepsis. The tannic acid-ferric nanoparticles, can incorporate vitamin D-3, coated with zwitterionic chitosan (ZWC) and polymyxin B (PMB).
US- 11865506- Pyraclostrobin Microcapsule Based On Sodium Alginate And Preparation Method
The present disclosure provides a pyraclostrobin microcapsule based on sodium alginate, made via emulsion in liquid paraffin and crosslinking at low pH.
US- 11865196- Engineered Radioactive Polymeric Microsphere, and Preparation and Application Thereof
An engineered radioactive polymeric microsphere made by adding a styrene monomer and crosslinker into a medium, polymerizing with an initiator under low oxygen followed by radiation-induced graft polymerization with a functional monomer to obtain the functionalized polymeric microsphere entrapping a radionuclide payload.
Bio
US- 11911516- Protection of Microbial Cells from Acidic Degradation
An enteric cellulose sulphate- based microencapsulation technology for encapsulating bacterial or other microbial cells of benefit to digestion (probiotics)
US- 11865211- Nanoparticle Complex Showing Improved Cellular Uptake Through Surface Modification Using Lipid and Manufacturing Method Therefor
The present disclosure relates to a nanoparticle complex that is taken into cells to be used for the treatment of diseases. Surfaces of nanoparticles are modified with a lipid-based material to enhance endocytosis and stability for delivery into spheroid-type tumor cells.
Consumer Products/ Cosmetics
US- 11896689- Method of Making A Clear Personal Care Comprising Microcapsules
A method of making a personal care composition that involves using a mixer to combine a personal care composition chassis with microcapsules. The mixer has a housing, a first fluid inlet, a second inlet, a fluid outlet and a rotor connected to the housing. The rotor has blades positioned within the housing to define cells between neighboring blades and the housing. The personal care composition chassis, which includes surfactants and water, is advanced along a flow path from the first fluid inlet toward the fluid outlet, while the microcapsules are transferred from the second inlet to the flow path by rotating the rotor. Air in the microcapsule composition is directed from inside the cells toward the second inlet, and the microcapsule composition is combined with the personal care composition chassis to form the personal care composition. The personal care composition is advanced from the outlet
