This article summarizes selected patents in the area of controlled release or delivery that were published from June 1, 2024 through August 31, 2024. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 12071355- Method For Producing Zirconium Dioxide Nanoparticles In The Presence Of An Amino Acid
This invention describes a process for making zirconium dioxide (ZrO₂) nanoparticles through hydrothermal treatment of zirconium IV compounds in acidic conditions using an amino acid. The resulting nanoparticles have high visible transmittance (≥20% at 400 nm and ≥95% at 800 nm) in water at 40% concentration.
US- 12059666- TiO.SUB.2.-surface Modified Bio-adsorbent
Description of a surface-modified bio-adsorbent made from Ziziphus mauritiana biomass particles with TiO₂ nanoparticles attached. The bio-adsorbent, in powder form, has particle sizes of 25 to 250 µm and is designed to remove organic dyes from wastewater.
US- 12051516- Method Of Manufacturing Advanced Composites And Coatings For Radiation Environment Shielding
Description of a radiation shielding employing a laminate stack configuration of various polymers and carbon fiber coated with nanoparticles of various forms of Boron to increase shielding of the laminate stack. Applications in environment of space.
US- 12043788- Environmentally Acceptable Wellbore Stability Additive
A treatment fluid to stabilize a wellbore wall consisting of a base fluid and an additive. The additive may include environmentally acceptable nanoparticles. This treatment can be used in and oil and gas operation.
US- 12037258- Process For Rapidly Manufacturing Ultrasmall Phase-change VO2 Nanomaterial
The invention describes a method for continuously producing composite nanoparticles by heating a precursor mixture with supercritical water, forming core particles, encapsulating them with another precursor and organic material.
US- 11999900- Surface-modified Nanoparticle Compositions and Related Applications In Subterranean Hydrocarbon Recovery
Surface-modified nanoparticles and surfactants are used in compositions and methods for enhancing hydrocarbon recovery from subterranean formations.
US- 11999918- Hydrocarbon Functionalized Carbon-based Nanomaterial and Method
A fuel mixture includes a fuel, ethanol, and modified graphene oxide (mGO) nanoparticles functionalized with a hydrocarbon.
Agriculture
US- 12041939- Enzyme-loaded Pollen-mimicking Microparticles for Organophosphate Detoxification of Insect Pollinators
A composition for detoxifying insect pollinators from one or more organophosphate pesticides, containing microparticles comprising: (i) a phosphotriesterase; (ii) nanoparticles; and (iii) a surface-active agent formulated in an aqueous suspension which may also contain an insect pollinator attractant.
US- 12011001- Sustainable Nanoparticle Formulation for Management Of Red Palm Weevil
A gold nanoparticle composition that includes Peperomia blanda or an extract from P. blanda for controlling or inhibiting the growth of red palm weevil by applying to the soil to protect the date palm plant.
Diagnostic/Sensing
US- 12064492- Cells Loaded with Gold Nanoparticles for Use In The Diagnosis and/or Treatment Of Melanoma
The invention refers to a subpopulation of progenitors of endothelial cells loaded with gold nanoparticles sensitive to excitation with infrared radiation with consequent release of thermal energy, for use in the diagnosis and treatment of solid tumors.
US- 12061200- Direct Detection of Single Molecules on Microparticles
Description of analyzing a biological sample using fluorescent agents and macro conjugates with core polymers or proteins and evaluating multiple analytes simultaneously with microparticles and fluorophore labels, using image acquisition and analysis.
US- 12050225- Ultra-fast And Highly Sensitive Chemiluminescent Immunoassay Method for Detecting Thyroid Stimulating Hormone
A chemiluminescence immunoassay for the detection of thyroid stimulating hormone using water-soluble CdTe quantum dots as a chemiluminescence reagent for detection of TSH at the level of single molecule detection.
US- 12043865- Genetic Probe for The Detection of A Single Nucleotide Polymorphism (SNP) Or A Single Nucleotide Modification Of A Target Nucleic Acid
A nanoparticle with an oligonucleotide probe with a tag incorporated via a linker group; along with reference probe anchored to the surface of the nanoparticle for the detection of single nucleotide polymorphisms.
US- 12042281- Fluorescent Nanomaterial Sensors And Related Methods
A set of sensors for the detection of an analyte concentration, such as an electrolyte and/or a blood gas. These may include a nanoparticle associated with the matrix material, and a signaling molecule (perhaps fluorescent) associated with the nanoparticle.
US- 12031185- Molecular Beacon Delivery System For Directly Detecting Circulating Tumor Cells In Blood, Method Of Preparing The System And Method Of Using The System
A molecular beacon delivery system for directly detecting circulating tumor cells in blood, comprising nanoparticles self-assembled by a polymer material, protamine, and a molecular beacon.
US- 12016668- Magnetic Induction Molecular Imaging Method and Magnetic Induction Molecular Imaging System for Biological Tissue Detection
A magnetic induction molecular imaging method and system for biological detection, comprising a detection bed, a magnetic nanoparticle device, a magnetic field generating device, a signal receiving and transmitting device, a magnetic field signal acquisition device and computer equipment allowing for scattered electric and magnetic field information/detection in a tissue field.
US- 12013395- Serodiagnostic Testing Device and System For Early-stage Lyme Disease Using A Multiplexed Immunoassay
A multiplexed vertical flow serodiagnostic testing device for diseases such as Lyme disease. A colorimetric signal is generated by nanoparticles captured on a sensing membrane containing disease-specific antigens. The testing device allows for simultaneous measurement of multiple antibodies and/or antigens.
US- 12007327- Optical Bio-sensing Device for Bio-material Analysis Using Up-conversion Nanoparticles, And Bio-material Quantitative Analysis Using the Same
An optical device with a transparent substrate covering a sample with target biomaterial that includes up-converting nanoparticles.
US- 11999885- Hydroporphyrin Beads with Narrow Fluorescence Emissions
Provided are fluorescent microparticles and/or nanoparticles that have a polymeric matrix and at least one porphyrinic macrocycle for calibration of multi-laser flow cytometers, confocal fluorescence microscopes, and/or differentially labeling cells and/or other biomolecules.
Pharma
US- 12065396- Lipids For Use in Lipid Nanoparticle Formulations
Lipid compounds for use as a component of lipid nanoparticle formulations for delivery of a therapeutic agent are described.
US- 12064512- Silyl Lipids Suitable for Enhanced Delivery of Anti-viral Therapeutics
This disclosure provides silyl lipid molecules for incorporation into lipid nanoparticles (LNPs).
US- 12064479- Lipid Nanoparticles for Delivery Of Nucleic Acids And Methods Of Use Thereof
Description of improved compositions of ionizable lipid nanoparticles for the delivery of therapeutic nucleic acids to cells.
US- 12059477- Nanomaterials
Compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.
US- 12053546- Stabilized Topical Formulations Containing Core-shell Microcapsules
Description of the use of microcapsules containing benzoyl peroxide, and microcapsules containing a retinoid both with inorganic shells for topical application.
US- 12054471- Thiocycloheptyne Derivatives and Their Use
The invention relates to the use of the novel thiocycloheptyne derivatives in coupling reactions with linkers and drugs and the use of the derivatives in advanced multifunctional drug delivery systems (drug-loaded) nanoparticles.
US- 12053551- Process Of Preparing MRNA-loaded Lipid Nanoparticles
An improved process for lipid nanoparticle formulation and mRNA encapsulation resulting in a composition of increased potency of mRNA encoded protein expression in vivo.
US- 12053550- Preparation And Use of Sugar-targeting Nanoparticles for Modifying SiRNA
The present disclosure discloses preparation and use of sugar-targeting nanoparticles for modifying siRNA. Providing cycloaldohexose as the targeting molecule facilitates the nanoparticles targeting the GLUT-1 protein on the capillary endothelial cell membrane on the blood brain barrier, and the nanoparticles are transferred to the brain with high efficiency.
US- 12054503- amphiphilic Material and Application Thereof in Preparation For Liposome
The present invention relates to an amphiphilic material in preparation of a liposome to effectively enter tumor cells for drug delivery.
US- 12053499- Sustainable Nanocomposition for Treatment Of Osteoporosis
A composition for treating osteoporosis comprising Acroceras macrum gold nanoparticles (AM-AuNPs)for treating osteoporosis.
US- 12049543- Copolymer Containing Cyclic Nitroxide Radical and Trialkoxysilyl In Side Chain, and Use Thereof
A copolymer of hydrophilic(PEG) and hydrophobic blocks(polystyrene), which can form nanoparticles, entrap an active and remain stable under acidic conditions. The hydrophobic segment contains moieties capable of scavenging radicals.
US- 12049564- Positively Charged Nanoparticles, Use Thereof, And Preparation Method Thereof
Provided are positively charged nanoparticles and their use in intracellular gene delivery.
US- 12036329- Mucoadhesive Dispersion Nanoparticle System and Method for Production The Same
A mucoadhesive dispersion nanoparticle system applicable in pharmacy, medicine and cosmetics consisting of 0.1 to 10 w % nanoparticles suspended in a 0.01 to 2.00% aqueous hydroxypropyl methyl cellulose.
US- 12036262- Edible Plant-derived Nanoparticles For Regulation Of Gut Microbiota
Description of an edible plant-derived nanoparticle encapsulating RNA for the treatment of gut dysbiosis, modulating bacterial growth, modulating inflammatory cytokines, reducing migration of bacterial from the gut to gut-associated bloodstream, etc.
US- 12037529- Luminescent Layered Composition and A Method for Using The Composition
A system of at least three layers, with sensitizers or emitters, and produces visible or UV light upon exposure to infrared light. It may include therapeutic agents, detection moieties, or uptake enhancers.
US- 12036328- Clay Nanoparticles for Medical Use
Compositions, processes, and methods involving clay nanoparticles, wherein each clay nanoparticle comprises an anionic component and a cationic component and the anionic component has the formula: [(Si8MgbLic)O20(OH)4] wherein 5.5<b≤6, and wherein c>0 and b/c>12.
US- 12029786- Composition And Method of MRNA Vaccines Against Novel Coronavirus Infection
Polymeric and liposomal nanoparticle carriers of RNA encoding spike protein epitopes (native and mutated) or mRNA cocktails that encode other critical viral genes for delivery by subcutaneous, intraperitoneal and intramuscular injections.
US- 12031128- Rapid Design, Build, Test, And Learn Technologies for Identifying And Using Non-viral Carriers
Polynucleotide Barcoded polymer nanoparticles produced by reversible addition-fragmentation chain Transfer (RAFT) for in vivo screening and therapeutic delivery.
US- 12023411- Dendritic Nanogel Carriers and Method of Production
A nanogel of self-assembled dendritic containing polymers having at least one dendritic hydrophobic segment forming the core and at least one hydrophilic segment forming the shell.
US- 12016937- Composition Of Radioactive and Non-radioactive Microparticles
A composition that includes a mixture of radioactive and non-radioactive microparticles for treatment of a vascularized tumor, such as a liver tumor or a metastasized liver tumor.
US- 12016958- Method For Delivering an Agent to Posterior Segment of An Eye And Uses Thereof
A method for delivering an agent to the posterior of an eye using mesoporous silica nanoparticles.
US- 12016897- Microparticles Containing Leuprolide and Method for Producing the Same
Microparticles containing leuprolide for controlled release.
US- 12011508- Methods And Devices for Reducing Vascular Smooth Muscle Cell Proliferation
A device comprised of a balloon coated with PLGA nanoparticles containing a therapeutic agent for treatment of peripheral artery disease.
US- 12011507- MRNA Delivery Composition
A lipid nanoparticle for extrahepatic delivery of mRNA exhibiting at least a 10% increase in gene expression of the mRNA in vivo as measured in one or more extrahepatic organs or tissues.
US- 12011487- Salvianolic Acid-gelatin Conjugate Hydrogel Particles
A formulation of salvianolic acid-gelatin conjugate load retentive hydrogel nanoparticles useful for oral delivery of salvianolic acid.
US- 12011473- Green Nanoparticle Composition for Treatment Of Histoplasmosis
A composition of silver nanoparticles made using leaf extract of Desmidorchis retrospiciens, as a novel antifungal therapy and treatment of histoplasmosis.
US- 12005126- Compositions for Oral Administration of Pentosan Polysulfate in Form of Nanoparticles With Improved Intestinal Absorption
A nanoparticle formulation for the oral delivery of Pentosan Polysulfate sodium (PPS).
US- 12006500- Composition And Methods of RNAi Prophylactics And Therapeutics For Treatment Of Severe Acute Respiratory Infection Caused By 2019 Novel Coronavirus (2019-nCoV)
Polymeric and liposomal nanoparticle carriers of RNA encoding epitopes of critical viral genes for delivery by airway instillation, subcutaneous injection, and nebulizer aerosolization
US- 12005125- Nanoparticles For Use in Photodynamic Therapies And Methods Of Making, Evaluating And Using The Same
A nanoparticle formulation for use in treating cardiac, oncologic, bariatric, or dermatologic indications, conditions using a phthalocyanine dye, such as IR700.
US- 11999770- Peptides And Nanoparticle Formulations Thereof
Peptides and nanoparticle formulations as inhibitors of protein-protein interactions, for treatment of diseases associated with overexpression of the RAN gene.
US- 11998616- Nanoparticles For Crossing the Blood Brain Barrier and Methods of Treatment Using The Same
Nanoparticles carrying therapeutic agents, including chemotherapeutic agents, and targeting ligands for delivery through the blood brain barrier.
US- 11998614- Compositions And Methods for Inducing Scarring by Peri-tumoral Cells
Composition of a nanoparticle, a linker and/or masking agent, and a ligand configured to activate peri-tumoral cells to induce scarring resulting in the walling-off and containment of invasive tumors.
US- 11998615- Functionalized Nanoparticles and Their Use In Treating Bacterial Infections
Treatment of bacterial infections with nanoparticles comprising a thiol-binding metallic core conjugated to a fluoroquinolone antibiotic.
US- 11998566- Method Of Synthesizing a Silver Nanoparticle Composition Using an Extract Of Salsola Tetrandra
Salsola tetrandra silver nanoparticles (ST-AgNPs) made by combining the Salsola tetrandra extract with silver nitrate. The nanoparticles can be used to treat or inhibit fungal infection, such as invasive pulmonary aspergillosis.
Bio
US- 12048714- Products And Methods for Organ Protection with Noble Nanoparticles
Products based on biologically compatible antioxidant noble metal nanoparticles to treat accumulation of reduced pyridine nucleotides observed in hypoxia and hypoxia-related disorders. These formulations can also be used in organ transplantation and recovery, in screening of anti-hypoxia agents, and in detecting elevated levels of the reducing equivalents of the redox state in cells, tissues, or organs.
US- 12042519- Freeze-dried Formulations Including Nanoparticles and Methods of Freeze-drying
Nanoparticles in freeze-dried products of biological materials to improve stability and reduce risk of collapse.
US- 12018135- Encapsulation By Cross-linking of Anionic Polymers by PH Induced Dissociation of Cation-chelate Complexes
Microencapsulation method using encapsulant, fiber or film forming compositions of a cross-linkable anionic polymer, a multivalent cation salt, a chelating agent, and a volatile base. The acidic chelating agent is titrated with a volatile base to an elevated pH to improve ion-binding capability. Vaporization of the volatile base during spray drying drops the pH of the solution causing the cation-chelate complexes to dissociate and liberate multivalent cations that associate with the anionic polymer to form a cross-linked matrix.
US- 12016931- Nanoparticles Comprising Peptides Including An N-terminal Linker
Nanoparticles comprising an amphiphilic polymer and a peptide of 8 to 50 amino acids that is covalently linked to the polymer, including an N-terminal linker sequence comprising at least one Arg amino acid residue and a sequence comprising an MHC binding sequence comprising a T cell receptor epitope for use in inducing tolerance to a therapeutic compound (protein, viral vector, lipid vesicle), an allergen or to an autoantigen or for treating an allergy, an autoimmune disease, an exogenous antigen or a food intolerance.
Consumer Products/ Cosmetics
US- 12053543- Sunscreen Composition Containing Visibly Transparent Biocompatible Ultraviolet Blocking Polymer Nanoparticles
A sunscreen composition containing visibly transparent biocompatible ultraviolet blocking polymer nanoparticles (PDMS).
US- 12048755- Microcapsule Compositions Prepared from Polysaccharides
Microcapsule compositions with each of the microcapsules having a single core-shell structure. The microcapsule compositions include pectin and are used in consumer products.
US- 12048341- Aromatic Microcapsule, Aromatic Chemical Fiber False Eyelashes and Preparation Methods Thereof
The preparation of the aromatic chemical fiber false eyelashes includes an aromatic microcapsule including a niobate. The core material solution further contains a silane coupling agent and an essential oil or fragrance.
US- 12031238- Cosmetic Fabric
Garment comprising a fabric formed by at least two yarns. The first yarn contains granules of material adapted to reflect/emit/ absorb infrared radiation. The second yarn has microcapsules containing at least one cosmetic compound.
US- 12023639- Flowable Core-shell Microencapsule Composition
A method for producing a flowable material containing core-shell microcapsules by mechanically removing solvent from a microcapsule suspension and charging the wet cake with a dry flow aid.
US- 12023640- Aqueous Dispersion of Microcapsules, And Uses Thereof
An aqueous dispersion of microcapsules comprising a hydrophobic core and a polymeric shell formed by the reaction product of at least one monofunctional or multifunctional unsaturated carbonyl compound, and at least one nanocellulose or microcrystalline cellulose for consumer product applications.
US- 12005132- Atomic Scale Topical Composition with Enhanced Interstitial Cellular Uptake for Increased Moisturizing, Fluidity, Antioxidant And Radiation Protection, Antimicrobial Cleansing And Therapeutics For Optimal Dermal Integrity And Homeostasis
A topical composition that integrates halogen-functionalized fullerenes and metallic nanoparticles (NPs) to provide comprehensive skin protection, sanitizing, cosmetic enhancement, and in some embodiments, treatment for various conditions. The formulation can deliver active ingredients across the skin to dermal layers.
Observations/Thoughts/Trends/Musings
It seems the patent submissions/approvals are “back to normal” this quarter as I reviewed just over 150 abstracts to compile the present list. Again, the topic of “Pharmaceuticals” was very popular in this tranche of published patents. There were also many industrial patents (many of which I omitted from these results, believe it or not!). As in past surveys, there were not many patents issued in the field of agriculture or foods.
I use my own list of search terms when browsing the patent literature and have resisted the urge to depend upon anything beyond Boolean search terms. I haven’t attempted to search for patents using some sort of AI-based search to date. However, that doesn’t mean AI doesn’t help with searching. A colleague here at SwRI brought a search assistant called Research Rabbit to my attention recently and it is proving to be useful. When starting with a paper, it can help you find relevant related papers. I am certain that many of us have gotten lost down a rabbit hole of paper searches often losing site of what we were actually searching for. There is simply too much good information at our fingertips these days. Research Rabbit can keep you on track and it can even sync with literature databases like Zotero should you so desire. I am sure there are other search assistants using AI out there. Please let me know of any you’ve found and I can mention them here. Happy hunting!
Were you able to attend the last annual meeting? Bologna was wonderful. Not only was it the largest conference from an attendance standpoint, the talks, posters, and venue were all top-notch(not to mention the food...). It is encouraging to see such a strong return to form for our Controlled Release Society and I am so excited to see what the future has in store for us. That includes our own e-newsletter as the committee met in Italy and are optimistic about the upcoming year.
Until next time.
Stay safe when navigating that AI universe. Don’t let Skynet become sentient. We all know how that ends…
KC
