Patent Watch: September - December 2024
This article summarizes selected patents in the area of controlled release or delivery that were published from September 1, 2024 through December 26, 2024. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 12163033- Ultra High Strength Coating and Composites
Method of producing a high strength nanoparticle enhanced composite. The polymer/nanoparticle composite can be produced cost effectively as a high-quality coating system or in nanoparticle concentrate forms.
US- 12163006- Compositions Containing Alumina Nanoparticles for Oil-water Separation
Compositions containing alumina nanoparticles covalently bonded to polyurethane, a fluorocarbon, and a group capable of undergoing protonation for use in oil-water separation applications.
US- 12146104- CO2 Responsive Core-shell Multi-stage Swelling Microsphere and Preparation Method Thereof
The present invention discloses a CO2 responsive core-shell multi-stage swelling microsphere. The CO2 responsive core-shell multi-stage swelling microsphere of the present invention can remarkably improve the CO2 flooding sweep efficiency thus increasing oil output in an oil reservoir.
US- 12140582- Multifunctional Polysaccharide-based Mud Logging Barcode Tracers
A nanoparticle tag containing a natural polysaccharide, fluorescent dye, and superparamagnetic nanoparticles is used to determine the origin of subterranean rock formations. By mixing the tag into a fluid, injecting it into the formation, and recovering samples, tagged and untagged rocks are separated using a magnet. The origin is identified by analyzing the fluorescent signal of the tagged rocks.
US- 12129090- Multifunctional Polysaccharide-based Mud Logging Barcode Tracers
A formulation consisting of a biodegradable resin and a microcapsule with a decomposition accelerator for the biodegradable resin. The microcapsule is composed of a shell material that degrades upon exposure to light.
US- 12102861- Extinguishing Material and Preparation Method Thereof
A perfluorohexanone microcapsule and its use in fire extinguishing powders, stickers, blankets, and fire-fighting clothes is described.
Agriculture
US-12167732 Alkali-resistant Calcium Phosphate/nucleic Acids Hybrid Carrier for Pest Control and Method to Produce the Particles
An aqueous suspension of calcium phosphate nanoparticles that include a nucleic acid. The nanoparticles may be used for protecting crops against insects and for down-regulating expression of a target gene in an insect pest species to prevent and/or control pest infestation.
Diagnostic/Sensing
US- 12163077- Ultrabright Luminescent Lanthanide Nanoparticles Comprising Terbium, With Longer Excited-state Lifetime
The invention provides luminescent lanthanide nanoparticles with better brightness and increased lifetime of the excited state.
US- 12162243- Superhydrophobic Platform for Sensing Urine Metabolites and Toxins
A composite superhydrophobic material with a layer of positively or negatively charged functional groups; a metal nanoparticle coating with a set of negatively or positively charged functional groups, a metal layer on top of the metal nanoparticle coating; and a first superhydrophobic layer on top of the metal layer.
US- 12097269- Dual Mode Gadolinium Nanoparticle Contrast Agents
Provided herein are nanoparticle-based gadolinium (Gd) agents . that deliver a higher concentration of Gd and result in substantial improvements in contrast and reduction of noise in MRI imaging and/or treating diseases such as cancer.
US- 12097264- Methods And Compositions for Theranostic Nanoparticles
A nanoparticle for drug delivery, made up of a hyperbranched polyester (HBPE) with a hydrophobic interior, and conjugated polyglutamate folate ligands with one or more PET detectable isotopes.
US- 12087405- Methods Of Processing a Biofluid Sample
Disclosed herein are methods and compositions for processing biofluid samples using nanoparticles to adsorb proteins present in a disease state such as lung cancer.
US- 12077450- Tantalum Oxide Nanoparticle Contrast Agents
A nanoparticle formulation with a core including tantalum oxide, and a coating covalently bound to the core. The covalent coating includes a surface modifier such as (3-aminopropyl)trimethoxy silane (APTMS), (3-aminopropyl)triethoxy silane (APTES), APTMS-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTMS-m-PEG-glutarate), APTES-methoxy-poly(ethylene-glycol)-succinimidyl glutarate (APTES-m-PEG-glutarate), 2-[methoxy (polyethyleneoxy)-9-12-propyl] trimethoxysilane (PEG-Silane), hexadecyltriethoxy silane, or combinations.
Pharma
US- 12162819- Ionizable Lipid Compounds
A class of ionizable lipid compounds used in the delivery of nucleic acids.
US- 12161734- Multimodal Silica-based Nanoparticles
The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring, and treatment of a disease such as cancer. The nanoparticle can be coated with an inorganic polymer to aid in urinary excretion and can be conjugated to a targeting ligand to increase specificity. It can also be detected using fluorescence imaging, PET, SPECT, bioluminescence CT, and MRI. Additionally, radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle.
US- 12151029- PEG Lipids and Uses Thereof
Description and use of PEG lipids in LNP formulations for various applications such as pharmaceutical compositions, cosmetic compositions, and drug delivery systems, e.g., for use in lipid nanoparticle (LNP) formulations.
US- 12129223- Lipids For Use in Lipid Nanoparticle Formulations
Description of lipids used as a component of lipid nanoparticle formulations for delivery of a therapeutic agent.
US- 12121591- Sulfur-containing Ionizable Lipids for The Delivery of Nucleic Acids And Other Therapeutic Agents
Provided herein is an ionizable, cationic amino lipid which may be formulated in a lipid nanoparticle for use in the delivery of charged cargo such as nucleic acid.
US- 12116603- RNA Silencing Nanozymes
A formulation of gold nanoparticles coated with nanozymes for targeting RNA. The nanozymes can also include additional capturer strands and/or involve DNA-recombinant-RNase-A unibodies to further increase the nanozyme's enzymatic activity and target selectivity. Core-free hollow forms are also described to reduce toxicity of the gold core and create a cavity for transport of other therapeutics.
US- 12115283- Sustained-release Injection Formulation Comprising Conjugate of Poly-L-lactic Acid Filler And Hyaluronic Acid Filler And Bioactive Materials, And Preparation Method Thereof
A biodegradable polymer double microcapsule that contains a conjugate of poly-L-lactic acid filler and hyaluronic acid for controlled release applications.
US- 12115250- Use Of Nanoparticles for Treating Respiratory Infections Associated with Cystic Fibrosis
A formulation of metal nanoparticles for treating respiratory infections associated with cystic fibrosis is described.
US- 12109271- Microparticle Systems and Their Use for The Treatment of Multiple Sclerosis
Provided are a dual microparticle system to treat Multiple Sclerosis, the system comprising phagocytosed and non-phagocytosed microparticles for delivery of at least one antigen, at least one immunomodulatory agent, at least one immunosuppressive agent and at least one chemoattractant.
US- 12109223- Polymer Nanoparticle and DNA Nanostructure Compositions and Methods for Non-viral Delivery
Description of polymer nanoparticles, designed as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, using DNA origami to deliver multiple payloads, or a nucleic acid construct payload of 3 kB or more.
US- 12109261- Stabilized Hemagglutinin (HA) Trimers as Influenza Vaccine Antigens
Novel engineered influenza hemagglutinin (HA) proteins, related polynucleotide sequences, and vaccine compositions including nanoparticle compositions are provided.
US- 12102686- Delivery Systems and Methods for Reactive Hydroxyl-containing Compounds
A formulation of poly(beta amino ester) (PBAE) for controlled release of curcumin that matches levels of oxidative stress.
US- 12102985- Metal Particle-loaded Hollow Mesoporous Organosilica Nano/microparticles And Method for Manufacturing Same
A hollow mesoporous organic silica nano/microparticle with metal particles on the surface for use as a delivery vehicle, a catalyst, and capable of a photothermal effect.
US- 12104181- Compositions And Methods for Treating Viral Infections Targeting TRIM7
Embodiments of this invention include lipid nanoparticles containing an mRNA encoding for a TRIM7 protein.
12102693- Pharmaceutical Composition with Nanoparticle-based Drug Delivery Combined with Non-invasive Radiographic Monitoring Model
A mesoporous silica nanoparticle (“MSN”); a bioactive agent loaded into the MSN; and an enteric coating for oral administration or combination for use in multiple pharmaceutical formulations.
US- 12097290- Membrane Encapsulated Nanoparticles and Method of Use
Nanoparticles comprised of an inner core of a non-cellular material and an outer surface comprising a cellular membrane derived from a cell or virus. These NP’s can be used for treatment of disease or vaccine formulations.
US- 12098167- Self-assembled Nanoparticle Containing GB Protein of EB Virus And Preparation Method and Use Thereof
Description of a self-assembled nanoparticle containing a gB protein of an EB virus on the surface of the particle resulting in higher gB antigen binding with neutralizing antibody.
US- 12097283- Method For Alleviating Dry Eye Syndrome
Disclosed herein is a method for alleviating dry eye syndrome using a composition containing a poly-lysine nanoparticle.
US- 12090235- Preparation Of Lipid Nanoparticles and Methods of Administration Thereof
Methods of producing lipid nanoparticle (LNP) formulations are described. The disclosure provides therapeutic and diagnostic uses of the produced LNP formulations.
US- 12083224- Lipid Particles for Nucleic Acid Delivery
A lipid-NA nanoparticle incorporated in pharmaceutical formulations for immunization against various diseases.
US- 12083162- Universal Nanosponge for Treating Respiratory Viral Infection
A nanoparticle coated with a plasma membrane containing the aCE-2 receptor that can be infected with a respiratory virus. Methods for preventing or treating viral infections, such as coronavirus infection are disclosed.
US- 12084703- Synthetic Self-amplifying MRNA Molecules with Secretion Antigen And Immunomodulator
Lipid nanoparticle (LNP) encapsulating self-amplifying mRNA are disclosed. LNP constructs include ionizable lipids, and self-amplifying-mRNA constructs that encode SARS-CoV-2 spike protein to be used in therapeutic, diagnostic, or prophylactic applications.
US- 12083153- Silver Nanoparticle Composition Including Biosynthesized Silver Nanoparticles and An Extract Of Farsetia Aegyptiaca
A silver nanoparticle composition for controlling or inhibiting the growth of P. jirovecii that includes an extract of Farsetia aegyptiaca (FA).
US-12077501 Compounds and Compositions for Intracellular Delivery of Agents
Nanoparticle compositions include an amino lipid, phospholipids, structural lipids, PEG lipids, or a combination for controlled release of therapeutic and/or prophylactic agents like RNA to regulate polypeptide, protein, or gene expression.
US- 12077483- Modified Amine Lipids
The disclosure provides ionizable amine lipids in nanoparticle-based formulations for the delivery of biologically active agents.
US- 12076443- Preparation Method of Nanozyme Composite-based Hybrid Hydrogel Eye Drop
A preparation method of a nanozyme composite-based hybrid hydrogel eye drop containing a silver/cobalt composite nanoparticle. The eye drop formulation displays a broad-spectrum bactericidal effect against a variety of bacteria and fungi to prevent/treat bacterial and drug-resistant bacterial corneal infections.
Bio
US- 12161725- Phage Mimicking Nanoparticles
An antibacterial nanoparticle (ANP) that includes a silica core conjugated to gold nanospheres, some silver-coated gold nanospheres and optionally, iron oxide nanospheres conjugated to one or more polycationic polymers and/or one or more antibacterial peptides.
US- 12161697- Nanospheres for Bone Fracture
Usage of albumin nanoparticles for stimulating bone heal by augmenting the function or effectiveness of stem cells or precursor cells in vivo. The albumin spheres can be bound with fibrinogen molecules in vitro or in vivo.
US- 12134672- Bacteria Repellant Polymer Composites
Description of a grafted silicone polyether and porous inorganic nanoparticle combined with bacteria repellant polymer composites.
US- 12083231- Starch-based Double-loaded Functional Nano Particle as Well as Preparation Method and Application
A starch-based double-loaded functional nanoparticle that has a nanoparticle size, high antioxidant activity and stability against environmental stress, and can be used for delivery, and stabilization of biologically active substances.
US-12077638 Methods of Generating Microparticles and Porous Hydrogels Using Microfluidics
Methods utilizing microfluidics for the oxygen-controlled generation of microparticles and hydrogels used in biological applications.
US- 12077750- Nanocaged Enzymes with Enhanced Catalytic Activity and Increased Stability
A nanoparticle comprising a DNA nanocage and a payload biological macromolecule.
Consumer Products/ Cosmetics
US- 12138610- Process For Preparing Mineralized Microcapsules
A mineralized core-shell microcapsule slurry, where the mineralized microcapsules have a mineral layer used in perfuming compositions and consumer products, in particular perfumed consumer products in the form of home care or personal care products.
US- 12122127- Microsphere-coated Polyurethane Articles and Methods Of Making The Same
A multilayered system comprised of microspheres in a monolayer, a bead bonding layer comprised of a thermoset polyurethane, a primer layer on the second major surface of the bead bonding layer comprised of a copolymer of polyurea and polyurethane covalently attached to the bead bonding layer and an elastomeric comprised of a polyurethane thermoplastic elastomer for use in paints and coatings where durability and weatherability are required-automotive, aircraft, spacecraft.
US- 12083195- Microparticles of Cellulose Nanocrystals with Pigment Nanoparticles Bound Thereto And Method Of Production Thereof
Microparticles comprising carboxylated, sulfated, or phosphated cellulose nanocrystals (CNCs) and pigment nanoparticles for use in cosmetics.
