Rate-Limiting Drug Release | Controlled Release Society

Questioning the Rate-Limiting Drug Release and Absorption Mechanisms from an Intramuscular Long-Acting Injectable Prodrug Nano-/Microsuspension: The Effect of Local Macrophage Depletion

Authors:

Nicolas Darville, Marjolein van Heerden, Stefaan Rossenu, Guy Van den Mooter, Sandra De Jonghe, An Vermeulena

Introduction Long-acting injectable (LAI) (pro)drug nano-/microsuspensions—aqueous dispersions of pure (pro)drug nano-/microcrystals—have shown potential as a drug delivery strategy over the past decade and are now recognized as an attractive formulation option for poorly water-soluble drug…