Fluorescent Imaging | Controlled Release Society

Fluorescent Imaging of COX-2 in Pathological Tissues by Fluorocoxib A-Loaded Nanoparticles

Authors:

Md. Jashim Uddin, Thomas A. Werfel, Brenda C. Crews, Mukesh K. Gupta, Taylor E. Kavanaugh, Philip J. Kingsley, Kelli Boyd, Lawrence J. Marnett, Craig L. Duvall

Introduction Overexpression of cyclooxegenase-2 (COX-2) is a hallmark of inflammation and an early event in carcinogenesis and cancer progression.1,2 Because COX-2 is expressed in virtually all solid tumors, it represents an ideal biomarker with broad impact for the early clinical detection of…