Biocompatible Dendritic Nanogels for Thermally Triggered Skin Penetration

Category
Controlled Release of Actives in Consumer Products
Year
2014
Authors
M. Asadian-Birjand, F. Rancan, J. C. Cuggino, K. Achazi, R. C. Mutihac, J. Dernedde, A. Vogt, and M. Calderon
Institutions
Department of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, 14195, Germany; Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, 10117, Germany
Summary

Herein, we present the development of Rhodamine B labeled thermoresponsive dendritic nanogels (dNGs), which penetrate in human skin upon a thermal trigger. The easiness of the synthetic approach enabled tailoring the nanogels properties, as size and transition temperature. Skin penetration studies highlight their strong potential for pharmaceutical and biomedical application.