A biomimetic strategy for gastric targeting based on Helicobacter pylori

Category

Overcoming Barriers in the GI Tract

Year

2014

Authors

Naim Hage, Sebastiaan Winkler, Paul Gellert, Snow Stolnik, and Franco H. Falcone

Institutions

University of Nottingham, Nottingham, Nottinghamshire, NG7 2RD, United Kingdom; AstraZeneca, Macclesfield, Cheshire, SK10 2NA, United Kingdom

Summary

The aim of our work is to develop a biomimetic drug delivery platform, for targeted delivery to the stomach, based on the bacterium Helicobacter pylori. Thus far, we have demonstrated our recombinant form of the bacterium’s main adhesion protein efficiently binds to specific receptors found on the gastric epithelium. Using this protein to target and localise drug vectors to the stomach represents an innovative approach to solving regionspecific drug absorption through the stomach and proximal small intestine.