Category
Proteins, Peptides, and Vaccines
Year
2014
Institutions
Pharmaceutical Orthopaedic Research Lab, Faculty of Pharmacy and Pharmaceutical Sciences,University of Alberta, Edmonton, AB, T6G 2E1, Canada
Summary
Novel bone-targeting Parathyroid Hormonepolyethylene glycol-Bisphosphonate (PTH-PEG -BP) conjugates were synthesized, characterized and evaluated for bioactivity, bone affinity and anabolic efficacy in-vitro/vivo. Simple bisphosphonate (BP) moieties were conjugated to PTH using heterobifunctional PEG linkers in order to impart bone specificity for PTH after administration in a rat model of Osteoporosis, secondary to ovariectomy. Results for bone volume and new bone formation by Micro-CT, electron probe micro-analysis, and histological analysis showed significantly improved anabolic bone formation on treatment of osteoporotic rats using bone-targeting PTH-PEG-BP compared to currently marketed unmodified PTH.