Category
Innovations in Oral Drug Delivery
Year
2014
Institutions
Drug Discovery, Delivery and Patient Care (DDDPC), School of Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston Upon Thames, Surrey, KT1 2EE, UK; Aston Pharmacy School, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Summary
Despite the large surface area available for drug absorption through oral route, physiological, biological barriers and poor biopharmaceutical properties of therapeutic agents reduce the bioavailability for orally administered drugs. Ion pairing approach was used to improve drug permeation via passive transcellualr absorption and never used to target active carrier transporters. The current study demonstrates that ion pairing could improve drug uptake via transporter proteins.
