Controlled Release of Poorly Soluble Drugs via Hot Melt Extrusion

Category

Oral CR - Pharmaceutical Formulations, Technologies, and Development Strategies

Year

2013

Authors

Zhuoyang “John” Lian, Adam Bell, Divya Tewari, Christian Seiler, Abdenour Djemai and Thomas Dürig

Institutions

Ashland Specialty Ingredients, Wilmington, DE 19808 USA; Pharmaceutical Sciences & Clinical Supply, Merck Sharp Dohme Ltd., Hoddesdon, UK

Summary

This study investigates the feasibility of hot melt extrusion (HME) combining polyvinylpyrrolidone with thermoplastic water soluble polymer hypromellose as a technique to simultaneously enhance solubility of poorly soluble drugs and facilitate the production of sustained release pellets that deliver the drug payload in a time frame of 8 hours.