Designing Sustained Release Encapsulates loaded with Water Soluble Oxidant: Carbamide Peroxide

Category
Advances in Process Engineering -- New Methods for the Production of Particles, Capsules, and Coatings
Year
2014
Authors
Fideline L. Tchuenbou-Magaia, James Gwyer, Nigel Young and Zhibing Zhang
Institutions
University of Birmingham, School of Chemical Engineering, B15 2TT, UK; Philips Research Laboratories CB4 0FY, UK
Summary

Carbamide peroxide (CP), a hydrogen peroxide (HP) releasing agent has been encapsulated as a model active of water soluble, sensitive and reactive active. A screening of commonly used encapsulation techniques placed spray cooling of solid CP as the most promising cost effective method with paraffin wax as a carrier. The release profile of HP was temperature dependent and was tuned to achieve fast or slow release using release rate modifiers.