Development and Characterization of Emulsomes for Macrophage Targeted Multidrug Therapy against Tuberculosis

Category

Drug Delivery for Developing Countries/Global Challenges

Year

2013

Authors

Swati Gupta Yashwant Pathak

Institutions

Nanomedicine Research Center, Department of Pharmaceutics, I.S.F. College of Pharmacy, Moga 142 001 (PB), INDIA; Department of Pharmaceutical Sciences, College of Pharmacy, USF Health, Tampa, FL, 33612, USA

Summary

Glyceryl tridecanoate (tricaprin) based nanosize lipid particles (emulsomes) stabilized by soya phosphatidylcholine (PC) were prepared as a new drug delivery system for alveolar macrophage targeting for the treatment of tuberculosis. Multidrugs (rifampicin, isoniazid, pyrazinamide) encapsulated emulsomes dry powder inhaler (DPI) resulted in high concentration of drugs in the lungs.