Category
Imaging and Characterization Techniques for Drug Delivery: Systems and Targeted Drug Delivery
Year
2013
Institutions
Department of Chemical Engineering and Biotechnology, University of Cambridge, CB2 3RA, United Kingdom
Summary
This work reports the first use of multi-nuclear (19F and 1H) magnetic resonance imaging (MRI) to study both dissolution media ingress and drug egress from a hydrophilic polymer matrix controlled release system in a USP-IV dissolution cell under pharmacopeial conditions. Spatial maps of water penetration, tablet swelling and dissolution, as well as the mobilization and distribution of the drug are quantified and visualized. Such comprehensive information is key for: (i) the correct interpretation of conventional drug dissolution profiles and (ii) the optimal design (QbD) of controlled release formulations.
