Doubled-layered emulsions as delivery systems to reduce the degradation of Coenzyme Q10 and control its release at the absorption site

The objective of this study was to design doublelayered emulsions that can minimize the degradation of Coenzyme Q10 (CoQ10) during storage and enable the gradual release at the absorption site. CoQ10 was dissolved in olive oil and emulsified in whey protein solution to prepare primary emulsions, followed by deposition of pectin to prepare secondary emulsions. The degradation of CoQ10 under UV radiation for 4 h was reduced from 74% for free CoQ10 to 16% for primary emulsion, 8% for secondary emulsion, and 6% for secondary emulsion cross-linked by calcium ions. The secondary emulsions reduced the release of CoQ10 during the simulated gastric digestion and gradually released CoQ10 during the simulated intestinal digestion.