The aim of the current research project was to study the effect of supercritical carbon dioxide (SC-CO2) on the physico-mechanical properties of cellulose polymers, Klucel™ LF, EF and ELF hydroxypropylcellulose (HPC) resulting from hot melt extrusion techniques, and to assess the plasticization effect of SC-CO2 on the polymers tested. The physico-mechanical properties as well as the tablet characteristics of the extrudates with and without injection of SC-CO2 and with pure polymers were examined. SC-CO2 acted as plasticizer for Klucel™ LF, EF and ELF and allowed for a reduction in processing temperature during the extrusion process. Bulk and tap density as well as surface area and pore volume of the extrudates processed with SC-CO2 increased compared to the extrudates processed without SC-CO2. Furthermore, the hardness of the tablets of the polymers with SC-CO2 was increased. Thus good binding properties and compressibility of the extrudates were positively influenced utilizing SC-CO2 processing.
Category
Solubilization Technology: A Key Enabler for the Delivery of Poorly Soluble Drugs
Year
2013
Institutions
Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS-38677, USA 2Pii Center for Pharmaceutical Technology, School of Pharmacy, The University of Mississippi, University, MS-38677, USA 3Ashland Specialty Ingredients, Solubilization Center of Excellence, Columbia, MD 21045, USA 4Ashland Specialty Ingredients, Wilmington, DE 19808 USA
Summary
