Evaluation of a Novel Lipid Based Nanoparticulate System for Ocular Drug Delivery

Category

Regional Delivery: Challenges in Ocular Delivery and Pulmonary Delivery

Year

2013

Authors

Ali Seyfoddin, and Raida Al-Kassas

Institutions

The University of Auckland, School of Pharmacy, Auckland, New Zealand

Summary

A novel drug delivery system based on Nanostructure Lipid Carriers (NLCs) coated with low molecular weight chitosan (LCH) was developed for the ocular delivery of Acyclovir (ACV) (Seyfoddin and Al-Kassas 2012). The in vitro and in vivo drug release studies from NLCs indicated that the system releases the drug in a controlled manner which could increase the ocular bioavailability of ACV. Moreover, NLCs were found not to be toxic in a number of in vitro eye irritancy assays.