High-throughput, slit-surface, core-sheath electrospinning: Improving the formulation and dissolution of poorly soluble drugs

Production of solid drug dispersions via electrospinning is one approach to improve formulation of poorly soluble drugs. We have produced core-sheath microfibers containing amorphous dispersion of itraconazole (ITZ) that exhibit enhanced drug solubility with controllable dissolution kinetics by using a novel high-throughput, slit-surface electrospinning process. Our technology overcomes the low production rates associated with eletrospinning and produces core-sheath fibers which further expand drug formulation options significantly.