Inactivated Polio Vaccination Using a Microneedle Patch

Category

Innovations in Micro-and Nano-Based Delivery

Year

2014

Authors

J. Joyce, C. Edens, H. Eichenbaum, N. Dybdahl-Sissoko, J. Norman, W. Weldon, S. Oberste, M. Prausnitz

Institutions

Georgia Institute of Technology, Atlanta, GA, 30332, USA; Centers for Disease Control and Prevention, Atlanta, GA 30333, USA

Summary

Microneedle patches were designed to simplify delivery of inactivated polio vaccine (IPV) and increase vaccine immunogenicity in support of global polio eradication. These patches were shown, for the first time, to be safe and effective in the rhesus macaque. We also showed that slow release of IPV in the skin increased vaccine immunogenicity compared to bolus dosing. In this way, IPV vaccination using a microneedle patch may facilitate mass vac-cination and increase vaccine immunogenicity.