Category
Mini Symposia – Cancer Epigenetics, Epigenetic Drugs and Delivery
Year
2014
Institutions
Associate Professor, Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, GA
Summary
Recently, it has been shown that a potent chemical inhibitor of S-adenosylhomocysteine hydrolase, 3-deazaneplanocin A (DZNep), modulates chromatin through indirect (i.e., reducing methyl group availability) inhibition of histone methyltransferases including Enhancer of Zeste Homolog 2 (EZH2). DZNep, a carbocyclic analog of adenosine, depletes cellular levels of the Polycomb Repressive Complex 2 (PRC2) components while inhibiting the associated histone H3 at lysine 27 trimethylation (H3K27me3).
