From Laboratory to Pilot Scale: Advanced Dosage Forms of Protein/Peptide Medicines

Category

Breakthrough Technologies

Year

2014

Authors

T. Jin Z. Hu, S. Yang, X. Hong, W. Yuan, F. Wu, H. Zhu, and Z. Yin

Institutions

Shanghai Jiao Tong University School of Pharmacy, Shanghai 200240, CHINA; BioPharm Solutions, Inc., New Jersey 08536, USA

Summary

We report two formulation processes to produce sustained-release microspheres of uniform sizes and 90%+ biologic encapsulation efficiency (named EasySphere), and phase-transition microneedle (PTM) patches capable for efficient and accurate transdermal delivery of proteins/peptides at pilot scale.