Lipid nanoparticles for organ-specific delivery of RNA

Category

Advances in RNA and DNA Delivery

Year

2014

Authors

H. Haas, D. Fritz, M. Meng, , L. M. Kranz, K. C. Reuter, M. Diken, S. Kreiter, S. Funari, D. Pawlowska, G. Brezesinski, U. Sahin

Institutions

Ribological GmbH, 55131 Mainz, Germany; TRON, 55131 Mainz, Germany; Universität Mainz, 55131 Mainz, Germany; HASYLAB, DESY, 26607 Hamburg, Germany; Max-Planck-Institute for Colloids and Interfaces, 14476 Golm, Germany

Summary

Novel nanoparticulate formulations for organ-specific delivery of nucleotides were developed. After intravenous (i.v.) injection into mice, RNA could be targeted either to lung or spleen, depending on the composition of the nanoparticles.