Multi-functional cationic dendrimers for connexin43 antisense oligodeoxynucleotide delivery in the treatment of wet age-related macular degeneration

Category

Regional Delivery: Challenges in Ocular Delivery and Pulmonary Delivery

Year

2013

Authors

I. D. Rupenthal, A. Stikkelman, I. Toth and C. R. Green

Institutions

Department of Ophthalmology, The University of Auckland, Auckland, New Zealand; School of Chemistry and Molecular Biosciences and School of Pharmacy, University of Queensland, Brisbane, Australia

Summary

Retinal delivery of genetic material is limited by the molecules’ stability and cellular uptake. This study investigated seven multi-functional dendrimer carriers for their ability to form complexes with connexin43 (Cx43) antisense oligodeoxynucleotides (AsODN) and efficiently deliver these molecules into retinal pigment epithelium cells with minimal cytotoxicity.