Multistage Vector for Controlled Oral Delivery of Anti-Inflammatory Drug in Inflammatory Bowel Disease Treatment

Category

Micro- and Nanoparticle Design

Year

2013

Authors

F. Leonard E.-M. Collnot,, C.-M. Lehr,, M. Ferrari and B. Godin

Institutions

Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, 77030, USA; Helmholtz Institute for Pharmaceutical Research Saarland; and Department of Biopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, 66123, Germany

Summary

A multistage nanodelivery vehicle was developed by loading of budesonide containing poly(lactic-coglycolic acid) (PLGA) nano-particles into silicon nanoporous microparticles. The combination of micro- and nanoparticles utilizes each of the strengths of each component to be employed in oral drug delivery to inflammatory bowel disease (IBD). Drug efficiency was tested in a recently reported by us in vitro model of IBD.