Nanogels as a Platform for Targeted Delivery of Cisplatin to the Brain Tumor

Category

Challenges Around Brain Delivery: Sampling Site Issues and Interspecies Extrapolations

Year

2013

Authors

N.V. Nukolova V.P. Baklaushev, A.S. Khalansky, G.M. Yusubalieva, I.L. Gubskiy, T.O. Sandalova, A.V. Kabanov,, V.P. Chekhonin

Institutions

Serbsky National Research Center for Social and Forensic Psychiatry, Moscow, 119991, Russia; Lomonosov Moscow State University, Department of Chemistry, Moscow, 119991, Russia; Russian State Medical University, Moscow, 117997, Russia; Research Institute of Human Morphology of the Russian Academy of Medical Sciences, Moscow, 117418, Russia; Center for Nanotechnology in Drug Delivery and Division of Molecular Therapeutics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7362, USA

Summary

This study demonstrated the tumor-specific drug delivery and superior anti-tumor effect in vivo of an anti-cancer drug using polyelectrolyte nanogels conjugated with monoclonal antibodies. These nanogels could be used as a platform for the targeted delivery of chemotherapeutic agents to the tumors.