A New Strategy to Enhance Antibiotic Load for Pulmonary Treatment of Cystic Fibrosis Infections: Ciprofloxacin Lipid Complex Loaded PLGA Nanoparticles

Category

Advances in Drug Delivery to the Lung

Year

2014

Authors

N. Günday Türeli, J. Juntke, A. Torge, A. E. Türeli, EM. Prinz, C. de Souza Carvalho, N. Daum, CM. Lehr and M. Schneider

Institutions

MJR PharmJet GmbH, Homburg, 66424, Germany; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, 66123, Germany; Pharmaceutics and Biopharmacy, Philipps University Marburg, Marburg, 35032, Germany

Summary

A novel “counter ion complex” method was developed to overcome the low drug loading efficiencies of antibiotics in biodegradable PLGA nanoparticles. This intriguing approach enhanced drug loading efficiencies by altering solubility characteristics and distinguished itself to serve for development of pulmonary nanoformulations for treatment of cystic fibrosis (CF) infections owing to its higher antibiotic load to deliver to the site of action.