Category
Evaluation and Characterization of Controlled Release Products and Production Processes
Year
2014
Institutions
School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom; Pharmaceutical Development, AstraZeneca, Macclesfield, SK10 2NA, United Kingdom
Summary
We have employed Raman spectroscopic imaging to investigate in real time and in-situ the dissolution mechanisms that underpin amorphous solid dispersions of poorly water soluble felodipine in a polymeric matrix of Kollidon VA64. It was found that the increase of the drug loading in the formulation leads to re-crystallisation of the active ingredient, negatively impacting the dissolution performance.