Targeted Cellular Interactions of Dendron Micelles using PEG linkers

Category

Nanoparticles in Tumor Treatment

Year

2014

Authors

Ryan M. Pearson, Matt Pasko, Marilyn Gaske, Petr Král, and Seungpyo Hong

Institutions

University of Illinois at Chicago, Chicago, Illinois, 60612, USA

Summary

The effects of PEG linker length on the cellular interactions of folic acid (FA)-targeted dendron micelles (DMs) were evaluated using a combination of confocal laser scanning microscopy (CLSM) and flow cytometry. The choice of PEG linker length was found to dramatically affect the cellular interactions of DMs ranging from minimal to over 20-fold compared to nontargeted DMs. The ability to tune the cellular interactions of the DMs through modulation of the PEG corona demonstrates their potential as a drug delivery platform.