Patent Watch
Patent Watch
Ken Carson, Southwest Research Institute, U.S.A
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This article summarizes selected patents in the area of controlled release or delivery that were issued from June 3, 2019 through September 1, 2019. Greater detail on each of these patents is given on the U.S. patent website.
http://patft.uspto.gov/.
US-10392452-Light generating microcapsules for self-healing polymer applications
A system made up of a set of microcapsules dispersed in a polymeric matrix with some capsules containing monomers and photoinitiators while others contain chemiluminescent reactants. The light generated by chemilumiscent means upon damage of the matrix is absorbed by the photonitiators leading to polymerization of the monomers and healing of the polymeric matrix.
US-10377944-Surface modified nanoparticles
Ligand-interactive agents are bound to the surface of nanoparticles allowing for binding of ligands to the particle surface that affect solubility/compatibility properties.
US-10370488-Stimulus-responsive poly (lactic-coglycolic)-based polymers and nanoparticles formed therefrom
PLGA-based polymers with pendant nucleophiles protected with photocleavable protecting groups. After deprotection, the polymers degrade rapidly. The polymer may be formulated as a nanoparticle, with an encapsulated payload, which may be an imaging agent, a bioactive agent or a pharmaceutical agent.
US-10364508-Method for producing single crystalline zinc oxide nanoparticles
A method for producing single crystalline zinc oxide nanoparticles that is scalable to production. Zinc oxide nanoparticles are generated by an acid-base reaction.
US-10361038-Carbonaceous nanoparticles, methods of making same and uses thereof
This patent describes fabrication of carbonaceous nanoparticles used as electrode and supercapacitor materials.
US-10376468-Block copolymers and self-assembling nanoparticles formed therefrom
A method for using block copolymers to generate nanoparticles specifically by self-assembly.
US-10358531-Crosslinked polymer nano-assemblies and uses thereof
A platform technology for delivery of therapeutics, diagnostics or imaging agents to biological sites. The technology involves the creation of nanoparticles
under non-emulsion conditions that incorporate the hydrophobic payloads.
US-10342879-Carrier nanoparticles and related compositions, methods and systems
Generation of carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid and a linkage cleavable under reducing conditions.
US10322452-Metal nanoparticles
A description of generating nanoparticles with a cavity.
US-10317400-Au multicomponent nanomaterials and synthesis methods
Use of a gold nanoparticle with a surface modification allowing for ligation of biomolecules. Synthesis methods are performed at room temperature.
US-10316873-Method and apparatus for forming multiple emulsions
Description of single-step methods to generate multiple emulsions that can be used to further generate microcapsules, microparticles, liposomes etc. Can potentially be used to include a distinct number of inner droplets in an outer droplet, and in some cases, nested droplets.
Petroleum Industry
US-10392555-Nanoparticle design for enhanced oil recovery
Description of a nanoparticle design for hydrocarbon recovery in subterranean formations. This design could be used in Enhanced Oil Recovery (EOR) by stabilizing an oil-in-water emulsion allowing for removal of hydrocarbons from the sub terrain.
US-10377938-Nanoparticle smart tags in subterranean applications
Description of nanoparticle smart tags that may be used in sub geologic formations to detect analytes of interest in real-time.
US-10351751-Wellbore sealant using nanoparticles
Describes the use of wellbore sealant that contains nanoparticles. The sealant is designed based on the particular permeability and pore throat size distribution of the wellbore. The pore structure of the wellbore is clogged by the nanoparticles in the suspension resulting in less loss of circulation material.
US-10308865-Polysaccharide coated nanoparticle compositions comprising ions
Description of enhancing hydrocarbon fluid recovery from subterranean regions by making and using a coated nanoparticle, a cross-linked carbohydratebased coating, and an ion selected from the group consisting of Li.sup.+, Na.sup.+, K.sup.+, Rb.sup.+, Cs.sup.+, Be.sup.2+, Mg.sup.2+, Sr.sup.2+, Ba.sup.2+, and mixtures thereof.
Diagnostic
US-10400268-Methods and kits for the detection of DNA
A method for detection of pathogenic DNA using RNA probes on metal nanoparticles. US-10384191-Star-shap nanoparticle and a method of using thereof to detect arsenic in a solution A star-shaped nanoparticle that adsorbs arsenic in solution allowing for its quantitation.
US-10400242-Methods for treating acute myeloid leukemia and nanoparticle complexes of miR-22 utilized therin
Composition and methods for treating AML using mircoRNA-22 complexed with a dendrimer nanoparticle made of PAMAM for delivery to cells.
US-10398663-Mitochondrial delivery of 3-bromopyruvate
Description of a gold nanoparticle targeted for delivery to cancer cell mitochondria using 3-bromopyruvate.
US-10398655-Two-stage microparticle-based therapeutic delivery system and method
Description of a system to deliver therapeutics into mucosal tissue. It is made of microparticles embedded within a chitosan hydrogel. The microparticles contain the therapeutic. The microparticles include chitosan as controlled release component.
US-10398651-Carrier-free nanoparticles
Nanocrystals of chemotherapeutics were prepared in a medium containing Pluronic F-127 and coated with albumin.
US-10391174-Metallic nanoparticles, preparation and uses thereof
A description of nanoparticles used to alter or destroy target cells, tissues, or organs when exposed to ionizing radiation.
US-10376587-High capacity diketopiperazine microparticles and methods
A description of diketopiperazine microparticles having high capacity for adsorbing a drug or active agent used for pulmonary delivery via inhalation.
US-10376580-Methods of treating cancer with antibody-albumin nanoparticle complexes comprising albumin, trastuzumab, and paclitaxel
Description of albumin nanoparticles containing trastuzumab, and paclitaxel for cell targeted cancer therapy.
Pharma
US-10376579-Nanoparticle complexes of albumin, paclitaxel, and anti-VEGF antibody for treatment of cancer
Description of albumin nanoparticles containing paclitaxel and anti-VEGF targeting antibodies for cancer treatment.
US-10370656-Nucleic acid functionalized nanoparticles for therapeutic applications
Materials and methods for modulating cellular uptake/effectiveness of functionalized nanoparticles.
US-10369230-Sustained release of a therapeutic agent from PLA-PEG-PLA nanoparticles for cancer therapy
Description of a structure that contains a cancer therapeutic within a membrane formed by PLA-EPGPLA with BSA and a targeting group on the outside of the membrane. Various molecular weights of PEG and PLA are described in the formulation set.
US-10369114-Cholestosome vesicles for incorporation of molecules into chylomicrons
A lipid vesicle used for transport of its payload across an enterocyte membrane allowing for processing into chylomicrons by way of the golgi apparatus.
US-10369113-Prostate specific membrane antigen (PSMA) targeted nanoparticles for therapy of prostate cancer
A nanoparticle coated with a urea-based smallmolecule peptidomimetic inhibitor of prostate specific membrane antigen (PSMA).
US-10369104-Targeted polymerized nanoparticles for cancer treatment
A hybrid polymerized liposomal nanoparticle comprising both polymerizable lipids and nonpolymerizable lipids. Actives can be loaded into the vehicle and targeting agents can be conjugated to its surface.
US-10363309-Targeted nanoparticle conjugates
Description of a PEGylated nanoparticle with at least one hydrophobic therapeutic agent coupled to its surface along with a targeting moiety coupled to PEG.
US-10363219-Method of preparing albumin nanoparticle carrier wrapping taxane drug
Description of an albumin nanoparticle carrier containing a taxane-type drug for cancer therapy.
US-10363215-Porous microparticles with high loading efficiencies
Description of microparticles that are highly porous. Pre size and architecture are controllable with this described method.
US-10342870-Nanoparticles for drug delivery
Therapeutic magnetic nanoparticles with a therapeutic agent on the surface of the nanoparticle by way of a hydrolysable linker.
US-10335420-Nanoparticle-based tumor-targeted drug delivery
An aqueous dispersion of tumor-targeting liposomes is described. The liposome membrane contains a leguumain-targeting lipid or a legumain-targeting lipid conjugated and PEG-conjugated lipid.
US-10307482-Nanoparticle complexes of paclitaxel, cetuximab, and albumin
Described are nanoparticle complexes comprising paclitaxel, albumin and anti-EGFR antibodies for cancer treatment.
Food/Nutraceuticals
US-10369176-Probiotic formulations and methods for use
A biocompatible microsphere, a biofilm-generating probiotic bacterium, a prebiotic, and/or a prebiofilmic. Methods for preparing and formulating the compositions and methods for treating or preventing a disease using the compositions are also provided.
Bio
US-10385311-Method of making biological tissue components
A method of preparing a biological composite matrix system by combining tissue microparticles with a curable medium. Tissue is pulverized, and then decellularized generating tissue microparticles. Microparticles are then mixed in a curable medium generating a composite matrix.
US-103639089-Iron oxide nanoparticles and methods of use thereof
Description of iron oxide nanoparticles being used to inhibit or eliminate biofilms and bacterial growth specifically in dental applications and the prevention and treatment of oral disease.
US-10342761-Method of encapsulating a nucleic acid in a lipid nanoparticle host
Generation of nanoparticles by the intersection of an aqueous nucleic acid stream with an organic solvent lipid stream at high linear velocities.
US-10307490-Lipid nanoparticle compositions for antisense oligonucleotides delivery
Description of a lipid nanoparticle composition that includes a macromolecule conjugated to a polymer that can also include a targeting agent.
Agriculture
US-10350569-Method for producing microcapsule
A technique for producing a microcapsule containing a pesticide in a fatty acid ester that delays release.
Consumer/Fragrance/Cosmetics
US-10308902-Microencapsulation of detergent components
Description of a microcapsule produced by crosslinking of a polybranched polyamine, which is used for stabilizing non-enzymatic detergent components.
