Patent Watch
Ken Carson, Southwest Research Institute, U.S.A.
This article summarizes selected patents in the area of controlled release or delivery that were issued from September 3, 2019 through December 3, 2019. Greater detail on each of these patents is given on the U.S. patent website http://patft.uspto.gov/.
US-10497940-Carrier-nanoparticle complex and preparation method thereof
Description of a carrier-nanoparticle complex and its preparation.
US-10494461- Raft agents and their use in the development of polyvinylpyrrolidone grafted nanoparticles
Description of a method to polymerize various PVP molecules on the surface of nanoparticles using RAFT agents.
US-10493418- Microcapsule material capable of reducing pollution containing polycyclic aromatic hydrocarbon, and preparation method and application thereof
Generation of a microcapsule by layer-by-layer self-assembly that can absorb polycyclic aromatic hydrocarbons from the environment. Bioremediation of wastewater is a specific application of this technology.
US-10485875- Nanoparticles functionalized with sulfur-containing polymers
A functionalized nanomaterial/nanoparticle, with a polythioaminal-functionalized surface used to attached therapeutic or diagnostic moieties.
US-10485739- High strength microcapsules
High strength, high integrity microcapsules containing a hydrophobic core material. Capsule consists of copolymers of select monomers through a multistep oil-in-water emulsification polymerization process.
US-10483440- Cadmium-free quantum dot nanoparticles
Quantum dot semiconductor nanoparticles with ions such as zinc, aluminum, calcium, or magnesium at their core are described as they are more stable against Ostwald ripening. The core may be coated with one (or more) shells of semiconductor material. Example shell semiconductor materials include semiconductors containing zinc, sulfur, selenium, iron and/or oxygen ions.
US-10471013- Process for producing polymeric microspheres
Description of a microsphere-producing process involving 1) microspheres formation; 2) microsphere quality control; 3) post formation microsphere treatment. Microsphere formation involves pressure homogenization through a porous membrane followed by solidification. Quality control is used to eject oversized particles followed by a post treatment of smoothing surfaces and removal of organic solvents in the matrix of the particles.
US-10456838- Method for producing metal nanoparticles
Preparation method of a metal nanoparticle.
US-10441935- Method of producing nanoparticle-in-oil dispersion
Description of industrial-scale production of a dispersion of nanoparticles in oil. Water-in-oil nano emulsion is the technique employed.
US-10441608- Continuous methods for treating liquids and manufacturing certain constituents (e.g., nanoparticles) in liquids, apparatuses and nanoparticles and nanoparticle/liquid solution(s) resulting therefrom
Summary of a methods to generate metallic-based nano- and micro-particles using a plasma source.
US-10440983- Microcapsules comprising lutein or lutein ester
Description of the process used to make a microcapsule containing lutein and/or lutein esters in a matrix of fish gelatin without an added emulsifier.
US-10427220- Nanoparticle production method, production device and automatic production device
This patent describes a continuous process to mass produce nanoparticles using a set of tubes with specific heating and mixing.
US-10418159- Amphiphilic magnetic nanoparticles and aggregates to remove hydrocarbons and metal ions and synthesis thereof
Description of a process to generate a ferromagnetic nanoparticle with a coating of lipophilic and hydrophilic compound. The particle is thus stable in water and can adsorb/emulsifiy large amounts of lypophilic and hydrophobic compounds. The inventor sees this as a tool to remove contaminants from wastewater such as hydrocarbons or metal ions.
US-10405542- Encapsulated payloads bonded to polymeric materials
Description of a microcapsule with an encapsulated payload reversibly bonded to a fibrous substrate via the cyclic compound.
Petroleum Industry
US-10487259- Polysaccharide coated nanoparticle compositions comprising ions
This patent describes the generation of a coated nanoparticle with a cross-linked carbohydrate-based (dextran) coating and an ion. The area of use is the treatment of a subterranean formation.
Diagnostic/Sensing
US-10493431- Nanodiamond supported catalytic nanoparticles and associated methods
A catalytic nanoparticle with a nanodiamond core and a thin-layer polymeric film on the surface that contains a catalyst for a reaction, or acting as a transducer/sensor.
US-10493098- Mesoporous silica-coated nanoparticles
This patent contains a description of metal oxide nanoparticles coated with mesoporous silica that can be used as a diagnostic tool or even therapeutic agents.
US-10492709- Magnetic probes for in vivo capture and detection of extracellular vesicles
The invention described in this case involves the use of a body-mountable device that can detect the presence or status of the analyte in vasculature by exerting a magnetic force to attract magnetic nanoparticles that contain probes for that analyte, and detecting the signal from those probes. This is described as a platform that can be used for cancer detection/monitoring.
US-10485886- Core-satellite nanocomposites for MRI and photothermal therapy
Description of core-satellite nanocomposites useful for photothermal and/or MRI applications. (e.g., tumor treatment and/or imaging). The inventors describe a core nanoparticle surrounded by a bio-compatible shell, and in some cases a satellite component attached to that shell. The core and satellite could be composed of near-IR photothermal agents, MRI contrast agents, or near-IR optical dye.
US-10478132- Glucose conjugated gold nanoparticle
This patent details a gold nanoparticle with PEG and 2deoxy-D-glucose.
US-10465030- Nanoparticles complexed with functionalizable enhanced affinity ligands and use thereof
Disclosed are functionalizable ligands, nanoparticles, preferably nanocrystals, complexed with ligands and their use for bio-imaging.
US-10421903- Carrier particle and preparation method thereof
Description of a nano or microsphere with a “sub-sphere” quantum dot associated with it. The main sphere may also be loaded with at least one type of quantum dot.
US-10408727- Screening of nanoparticle properties
This invention involves the use of a screening chip to analyze nanoparticles. The chip has a set of areas dedicated to various surface energy components.
US-10406249- Gd(III)-dithiolane gold nanoparticle conjugates
Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
Pharma
US-10493150- Nanoparticle complexes of paclitaxel, alemtuzumab, and albumin
Described are nanoparticle complexes comprising paclitaxel, albumin and anti-CD52 antibody. The nanoparticle complexes are suitable for the treatment of cancer, in particular cancer that expresses CD52.
US-10493054- Docetaxel albumin nanoparticle pharmaceutical composition, preparation method therefor and use thereof
This patent describes an albumin nanoparticle containing docetaxel and a method to generate the particle as a treatment for cancer.
US-10487207- Bioenvironment-sensitive nanoparticle comprising polymer having complementary charges
Describes a “bioenvironment-sensitive nanoparticle” and the method of manufacturing the same. The bioenvironment-sensitive nanoparticle can be useful in stably and effectively delivering a target material such as a drug even when used at a small quantity since the nanoparticle is stable in extracellular environments. The nanoparticle can be useful in selectively diagnosing or treating cancer cells.
US-10485881- Nanoparticle drug conjugates
Nanoparticle drug conjugates (NDCs), which could comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties and imaging agents.
US-10478495- Methods for treating cancer using nanoparticle complexes of paclitaxel, cetuximab, and albumin
This patent describes an antibody-albumin nanoparticle containing cancer treatment molecules.
US-10471011- In vivo stealth nanoparticle
This invention involves a molecular imprint polymer incorporated into a nanoparticle. The molecular imprint polymer has a plasma protein recognition site, which provides in vivo stealth for intravascular delivery. As the plasma protein, albumin is preferred the invention is usable as a drug for drug delivery system.
US-10468559- Quantum dot nanoparticles having enhanced stability and luminescence efficiency
Quantum dot particles with strongly-binding ligands that are capable of coordinating to both positive and negative atoms on the surface of the nanoparticle. The ligands are bi-dentate and thus their approach to the QD surface is not as sterically hindered as mono-dentate ligands.
US-10463752- Protein polymer gold nanoparticle hybrid materials for small molecule delivery
A protein polymer-gold nanoparticle with a gold core and a plurality of protein polymer molecules coordinated to the gold core that can be used for small molecule delivery.
US-10463626- Drug delivery composition comprising polymer-lipid hybrid microparticles
A description of a dry , 3D composition of porous microparticles comprised of an active, polymeric nanoparticles of a biocompatible and/or biodegradable polymer (eg PLGA), lipid droplets (egMCT), a stabilizing agent such as (PVA or DMAB), and optionally, a cryoprotectant (eg mannitol). The average diameter of the individual microparticles of the composition may be in the order of 2.5-3.5 microns, which are particularly suitable for administration to the lung.
US-10463619- Injectable delivery of microparticles and compositions therefor
This invention describes the methods to generate particles that have improved injectability through narrow needle gauges than other particle compositions prepared from biocompatible or biodegradable polymers such as poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate.
US-10456467- Nanoparticle delivery system for targeted anti-obesity treatment
A magnetic nanoparticle including a TRPV1 agonist, as well as methods of preparation and use, are described. Magnetically responsive actives can be included in the core which can then be targeted to a tissue region using magnetism.
US-10449161- Pharmaceutical compositions for inhalation
The invention provides methods to generate microparticles for pulmonary administration. The microparticles have on their surface particles of a hydrophobic material that delays the dissolution of the active in the core.
US-10449152- Drug loaded microspheres for post-operative chronic pain
The invention describes a microsphere containing a local anesthetic that releases 75% of the active within 72 hours, 80%-90% in 120 hours, and relieves chronic pain for at least 28 days.
US-10441529- Cavitation-inducing polymeric nanoparticles
This patent is a description of a nanoparticle with a cavity that contains a gas pocket that can release an active upon exposure to ultrasound.
US-10426734- Taste masking drug formulations
This is a description of a microcapsule with a hydrophobic, pH-responsive shell to prevent release in the oral cavity (neutral pH), but upon exposure to the low pH of the stomach.
US-10413509- Pharmaceutical composition, preparation and uses thereof
This patent is a description of a biocompatible nanoparticle with a pharmaceutical payload. The particles range in size between 4 and 500 nm with an absolute surface charge of 10mV.
US-10406228- Process for making iron oxide nanoparticle preparations for cancer hyperthermia
Iron oxide nanoparticle compositions, methods of preparing the nanoparticles using high gravity controlled precipitation (HGCP), and methods of using the nanoparticles are disclosed.
US-10406161- Risperidone sustained release microsphere composition
Description of a risperidone sustained release microsphere formulation comprised of the active and a blend of PLGA’s to achieve the desired release profile. The method used is suitable for large-scale production.
US-10406111- Gold/lanthanide nanoparticle conjugates and uses thereof
The present disclosure describes gold/lanthanide nanoparticle conjugates, such as gold/gadolinium nanoparticle conjugates, nanoparticle conjugates including polymers, nanoparticle conjugates conjugated to targeting agents and therapeutic agents, and their use in targeting, treating, and/or imaging disease states in a patient.
Food/Nutraceuticals
US-10415002- Enhanced deposition of ethyl vanillin or vanillin with friable microcapsules
This patent describes a method to generate a friable microcapsule containing vanillin and/or ethyl vanillin.
Bio
US-10485885- Compositions and methods for delivery of agents
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods for delivering agents in vivo including nucleic acids and proteins. These formulations are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.
US-10478402- Solid nanoparticle with inorganic coating
This patent describes a nanoparticle having a solid core with a biological active, enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy.
US-10465189- Multilayered nanoparticle and methods of manufacturing and using the same
The invention relates to a multilayered nanoparticle for delivery of RNA to a cell. The multilayered nanoparticle has a core nanoparticle coated by alternating positively and negatively charged polymer layers, where at least one of the negatively charged polymer layers is RNA.
US-10463627- Therapeutic nanoparticles and methods of use thereof
Described is therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, with a polymer coating, and an siRNA payload for cancer therapy.
US-10456481- Dually derivatized chitosan nanoparticles and methods of making and using the same for gene transfer in vivo
Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.
US-10442756- Compounds and compositions for intracellular delivery of therapeutic agents
Provided within are descriptions of nanoparticles made from novel lipids and combinations with various know lipids. Nanoparticles are used for RNA delivery as well as other therapeutics.
US-10434149- Synthetic platelets
A method of promoting hemostasis in a subject by using a biocompatible flexible nanoparticle that includes a set of peptides conjugated to the surface including von Willebrand factor-binding peptides (VBPs), collagen-binding peptides (CBPs) and an active platelet GPM-Ma-binding peptides (GBPs).
US-10434070- Use of nanoparticles coated with red blood cell membranes to enable blood transfusion
This patent describes the development and use of a nanoparticle with an outer layer comprising a cellular membrane derived from a red blood cell comprising a blood type antigen that exists on the red blood cell from the donor but missing or potentially missing on red blood cells of the recipient.
US-10434068- Use of decellularized extracellular matrix for encapsulating cells
A microparticle for cell encapsulation that has a core of decellularized extracellular matrix (ECM) and, optionally, an outer layer. The core could contain small molecules, biomolecules or even cells.
US-10434047- Buffered microencapsulated compositions and methods
A microcapsule with a polymer as a semi-permeable shell around an aqueous buffered solution and at least one agent, wherein the agent permeates the shell, and is suitable for delivery to a mammal.
US-10426842- Targeted nanoparticle conjugate and method for co-delivery of siRNA and drug
Provided are nanoparticle conjugates comprising a drug encapsulated in a gelatin
nanoparticle the surface of which is functionalized with an antibody to which a siRNA is linked.
US-10415035- Anionic polyplexes for use in the delivery of nucleic acids
The invention describes an anionic polyplex formed from a nucleic acid and an anionic polymer and cation, which can be in the form of a nanoparticle or a microparticle. This particle can be used for delivery of the nucleic acid into cells for disease treatment. The invention also provides an anionic complex comprising a divalent cation and a nucleic acid but no anionic polymer, in the form of a nanoparticle that is capable of forming a colloidal suspension.
US-10406182- Stem cell microparticles and miRNA
This patent describes stem cell microparticles and miRNA isolated from these microparticles as a cancer therapy. The stem cell microparticle is typically an exosome or microvesicle and may be derived from a neural stem cell line. The neural stem cell line may be a conditionally-immortalized stem cell line such as CTX0E03 (deposited at the ECACC with Accession No. 04091601).
Cosmetic
US-10493005- Microcomplex for use in photoepilation process to obtain it and composition containing it
The patent describes a microcomplex containing a modified nanoparticle adsorbed on a host microparticle and the process to generate it. The microcomplex is particularly useful for photoepilation.
