Patent Watch
This article summarizes selected patents in the area of controlled release or delivery that were issued from August 2, 2022 through October 18, 2022. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 11473010- Nanoparticle Coated Proppants and Methods Of Making And Use Thereof
Describes the use of proppants containing functionalized nanoparticle coatings used in the petroleum industry.
US- 11473202- Anti-corrosion Nanoparticle Compositions
A formulation including a carrier containing nonionic metal nanoparticles. The nanoparticles selectively migrate to the grain boundary of a metal part in order to reduce corrosion of the metal or alloy.
US-11466199- Synergistic Enhancement of Slickwater Fracturing Fluids
A slickwater fracturing fluid that includes a brine with dissolved solids, an anionic friction reducing additive, a polysaccharide, and a nanomaterial that includes nanoparticles with an average particle size between about 1 nm and about 500 nm. This combination reduces friction and increase viscosity enhancing the proppant capability of the formulation.
US-11447686- Low Molecular Weight Polyacrylates For EOR
Describes method of making and the use of low molecular weight polyelectrolyte complex nanoparticles used to deliver agents into hydrocarbon reservoirs.
US-11435333- PH-sensitive Nanoparticles for Detecting and Preventing Food Spoilage
Nanoparticles and compositions thereof are provided for detecting and/or preventing food spoilage. The nanoparticles can have a hydrophobic core containing a hydrophobic active agent, e.g. a hydrophobic dye and/or an antimicrobial agent, for detecting and/or preventing food spoilage. The nanoparticles can also have a copolymer of a hydrophobic polymer repeat unit, e.g. styrene or lactic acid, and a pH responsive dendrimer allowing for the release of the hydrophobic agent to indicate spoilage or an antimicrobial to inhibit it.
Agriculture
US- 11419331- Microencapsulated Acetamide Herbicides
Description of weed control formulations comprising microcapsules containing an acetamide herbicide and processes to prepare them.
Diagnostic/Sensing
US- 11471542- Curcumin-based Magnetic Nanostructured System for Dual Response Of Imaging And Therapeutics
Silica nanocarriers hybridized with superparamagnetic iron oxide nanoparticles (“SPIONs”) and curcumin. Methods for delivery of SPIONs and curcumin to a target for diagnosis or therapy. Examples of functionalization with chitosan, polyacrylic acid, PLGA or another agent to increase its biocompatibility are given.
US- 11459406- Nanoparticles Adsorbed with Gliadin Molecules
Description of methods of preparing nanoparticles adsorbed with gliadin molecules and using them for detecting anti-gliadin 5 antibodies in a sample, diagnosing gluten-related disorders, and other applications.
US- 11446391- amphiphilic Dye-coated Inorganic Nanoparticle Clusters
Description of amphiphilic dye-coated inorganic nanoparticle clusters for use in imaging and treatment. Specifically, the invention relates to cyanine and/or cyclic tetrapyrrole dye-coated metallic nanoparticle clusters.
US- 11426355- Color-coded and Sized Loadable Polymeric Particles for Therapeutic And/or Diagnostic Applications and Methods of Preparing And Using The Same
Polymeric particles are provided for use in therapeutic and/or diagnostic procedures. The core-shell particles of specific sizes can be used for selective embolization or localized treatment. A color-coding functionality can be included to assist in identification of certain sized or loaded particles for specific applications/treatments.
US- 11419955- Multimodal Silica-based Nanoparticles
Describes a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. For further imaging/detection, radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle.
US- 11413683- Synthesis of Functionalized Gold Nanoparticles and Nano compounds Containing Same for Measuring Sucrose or Starch in Cells
A nanoparticle formulation for measuring sugars and starch in cells is described. Gold nanoparticles are functionalized with polymer ligands, for the selective measurement of sucrose or starch in intracellular fluid.
US- 11401463- Luminescent Particles Based on Rare Earth Elements and Use Thereof As A Diagnostic Agent
This patent describes the manufacture and use of particles made up of yttrium, gadolinium, and various lanthanide series elements for use in diagnostics.
Pharma
US-11471412- Nanoparticles and Nanogel Drug Compositions for Treatment of Age-related Macular Degeneration
Disclosed are nanoparticles and nanogel drug compositions and their use for treating age-related macular degeneration.
US- 11471420- Membrane Lipid Coated Nanoparticles and Method of Use
Disclosed is a nanoparticle comprising an inner core comprising a virus; and an outer surface comprising a cellular membrane derived from a cell. An example given utilizes an oncolytic virus surrounded by a cell membrane derived from a red blood cell.
US- 11471410- Pharmaceutical Composition Combining At Least Two Distinct Nanoparticles and A Pharmaceutical Compound, Preparation and Uses Thereof
Here, a combination of at least two distinct biocompatible nanoparticles with a compound of interest is described in which the particles enhance the efficacy of the active.
US- 11471515- Restoration of Tumor Suppression Using mRNA-based Delivery System
Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.
US- 11471421- Process for Preparing Microparticles Containing Glatiramer Acetate
An improved process for preparing microparticles containing glatiramer acetate having low levels of residual organic solvent(s), in particular dichloromethane is described. The particles act as a depot release mechanism for treatment of multiple sclerosis.
US- 11471525- Coronavirus Vaccine
This invention centers around specific nucleic acid sequences suitable for the treatment or prevention of infection by coronavirus especially SARS-CoV-2. Descriptions of use of the NA with polypeptides and lipids (LNPs) are also given.
US- 11472766- Lipid Nanoparticle Composition
Lipid nanoparticles for delivery of therapeutic agents (e.g., nucleic acid molecules) for therapeutic or prophylactic purposes, including vaccination are described.
US- 11471482- Nanoparticles for Use in Enhancing Brain Performances or In Treating Stress
Description of nanoparticle preparations that are not affected to external electrical fields. The nanoparticles themselves are made up of conductive, semiconductive and insulating materials and do not need be exposed to any other external activation source.
US- 11471419- Capsules with Intracapsular Microspheres for Improved Survival and Function of Encapsulated Cells
Description of a microcapsule containing a cell, a distinct polymer and a second microsphere containing a compound that improves survivability of the cell. Islet cells for treatment of insulin deficiencies are mentioned as an application of this technology.
US- 11466055-Virus-like Nanoparticles for Oral Delivery
A Hepatitis E virus (HEV)-based virus like nanoparticle (HEVNP) made with a modified capsid protein containing at least a portion of a protein conjugated with gold nano cluster is provided for targeted delivery of nucleic acids.
US- 11464740-Method and Devices for Delivering Therapeutics by Oral, Respiratory, Mucosal, Transdermal Routes
Description of a porous wall hollow-glass microsphere used to deliver a therapeutic. The pores of the glass shell are capped by an outer shell to retain the cargo until release is required.
US- 11464897-Compositions, Devices and Kits for Selective Internal Radiation Therapy
Description of an internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. Dosing regimens for breast cancer and hepatocellular carcinoma are described.
US-11464870-Lipid Nanoparticles for In-vivo Drug Delivery, And Uses Thereof
Lipid nanoparticles for delivery to the liver of a gene therapeutic agent.
US-11464748-Particles for Targeted Delivery and Uses in Managing Bleeding Or Blood Clotting
Description of particles comprised of layers of anionic polymers and cationic polymers that can be coated in fibrinogen containing a polysaccharide core and/or a polysaccharide coating encapsulating drug, proteins, clotting agents, coagulation factors, or anticoagulants.
US-11464858-Magnetic Nanoparticle Delivery System for Pain Therapy
Preparation and use methods for magnetic nanoparticles with a non-narcotic analgesic. The magnetic particles are directed to a particular region using an external magnetic field.
US-11464823-Curcumin Carbon Quantum Dots and Use Thereof
An engineered nanoparticle having a curcumin carbon quantum dot and its use in antiviral applications is described.
US-11458206-Targeted Conjugates and Particles and Formulations Thereof
Nanoparticles and microparticles, containing conjugates of an active agent attached to a targeting moiety, such as a somatostatin receptor binding moiety are demonstrated as a method to treat or prevent cancer or infectious diseases.
US-11458106-Lipid Nanoparticles Comprising Lipophilic Anti-inflammatory Agents and Methods of Use Thereof
Description of lipid nanoparticles with at least one lipophilic anti-inflammatory agent, and pharmaceutical active. Examples of payloads such as nucleic acid segments to target cells and tissues are given.
US-11458209-Compositions and Methods for Delivery of Nucleic Acid-lipid Nanoparticle Complexes Encoding For Viral RNA Polymerase Region And Protein Antigen
A formulation of lipid nanoparticles containing nucleic acids coding for viral RNA polymerase region and protein antigens is described. Applications include immune stimulation therapy and vaccination. The particles can also contain inorganic nanoparticle for use in in vivo imaging.
US-11452771-Scaffolded HIV-1 Env GP140 Trimer Immunogen
The present invention provides nanoparticles containing scaffolded HIV-1 vaccine immunogens for treating or preventing HIV infections.
US-11453639-Lipids for Lipid Nanoparticle Delivery Of Active Agents
Description and use of specific lipid materials to generate lipid nanoparticles for the delivery of therapeutic agents is described.
US-11446394-Lipid Nanoparticle Formulations Comprising Lipidated Cationic Peptide Compounds for Nucleic Acid Delivery
Description of lipid nanoparticle formulations comprising lipidated cationic peptide compounds and other lipid components including structural lipid, phospholipid and shielding lipids for delivery of nucleic acids.
US-11446390-Antigen Capturing Nanoparticles for Use In Cancer Immunotherapy
Formulation and therapeutic use of nanoparticles that capture antigens released from tumor cells.
US-11446392-Biomimetic Vesicles and Uses Thereof
Core-shell nanoparticle formulations that can take the form of clusters mimicking platelets used in therapy for vascular stenosis and restenosis.
US-11446267-Nanoparticle Compositions, Methods of Fabrication, And Use For Drug Delivery
A formulation of nanoparticles with a retinoid payload for the treatment of neurological disorders and preserving motor function and reducing neuroinflammation.
US-11439690- Methods of Treating Spinal Cord Injury
A formulation containing encapsulated superoxide dismutase and catalase for treatment of spinal cord or neuronal injury or neurodegenerative disease.
US-11439609- Nitric Oxide Releasing PLGA Microspheres for Biomedical Applications
Describes a PLGA microsphere with RSNO adduct that releases nitric oxide when exposed to light or moisture.
US-11439685- Formulations for Treating A Fibrotic Disease
The present invention provides formulations for the treatment of fibrotic diseases and disorders. In some embodiments, the formulation comprises a microparticle that includes an antifibrotic.
US-11433136- Polyacetal Polymers, Conjugates, Particles and Uses Thereof
General description of polymers and particles with various targeting moieties and pH-triggered release mechanisms for enhanced delivery and therapeutic uses.
US-11433123- Sustained Release Cowpea Mosaic Virus or Virus-like Particle Therapeutic Constructs For The Treatment Of Cancer
Nanoparticle-based therapies for cancer including melanoma, breast, colon, lung and ovarian cancers. The nanoparticles consist of a payload of cowpea mosaic virus or virus-like particles coupled to G4 dendrimers through electrostatic interactions.
US-11433260- Cancer Treatment Methods Using Thermotherapy And/or Enhanced Immunotherapy
Nanoparticle formulations for cancer treatment that include antitumor antibodies, cell penetrating peptides and a therapeutic payload (medicinal or gene in nature). The nanoparticles can also incorporate a dye or indicator in the polymer coating and/or surface antigens for targeting. Ultrasound can be used to excite the particles, remove the polymer coating and release the dye, indicator, and therapeutic for imaging/detection and treatment.
US-11433026- Nanoparticle-induced Fusogenicity Between Liposome and Endosome Membranes For Targeted Delivery Through Endosomal Escape
Formulation that incorporates hydrophobic nanoparticles into the membranes of vesicular delivery vehicles enhancing the endosomal membrane “fusogenicity” of the formulations leading to enhanced endosomal escape of the delivery vehicle and facilitating the delivery of the active. The payload can include combinations of biologically active molecules and materials, including therapeutic and diagnostic agents.
US-11433143- Nano-enabled Immunotherapy in Cancer
A platform technology for immune therapy in the treatment of cancer is provided. Payloads in a lipid nano vesicle can include cell death inducers and or an IDO pathway inhibitor for treatment of pancreatic cancer.
US-11433142- Compositions and Methods for Delivery Of RNA-lipid Nanoparticle Complexes Encoding For Viral RNA Polymerase Region And Protein Antigen
An RNA-lipid nanoparticle complex encoding for viral RNA polymerase region and protein antigen. The lipid particles can also contain inorganic nanoparticles for imaging.
US-11426391- Pharmaceutical Compositions
Stable, amorphous hybrid nanoparticles, comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component, useful in pharmaceutical compositions and in therapy involving poorly water-soluble actives.
US-11427637-Methods of Treating PD-L1 Expressing Cancer
Described herein are methods, formulations, and kits for treating a patient with cancer with nanoparticle complexes comprising a carrier protein, a binding agent and paclitaxel and optionally co-treated with an anti-PD-L1 antibody.
US-11426357-Mangiferin Encapsulated Gold Nanoparticles, Fabrication Methods and Cancer Therapeutic Methods
A method for forming mangiferin encapsulated gold nanoparticles and their use as a treatment for cancer by direct tumor injection.
US-11426457-MHC Class I Associated Peptides for Prevention And Treatment Of Zika Virus
The invention provides a vaccine composition comprising a flavivirus peptide comprising one or more CD8+ T cell C1 epitopes, wherein the peptide is attached to a nanoparticle.
US-11426422-SHP2 Inhibitors and Methods Of Use Thereof
Provided are methods for the treatment of insulin resistance and insulin receptor diseases with SHP2 inhibitors, such as allosteric inhibitors of SHP2 and RNAi or siRNA that target SHP2 expression. The inhibitors are formulated in liver-targeting liposomes or nanoparticles.
US-11419826-Surface-modified Mesoporous Silica Nanoparticle For Blood-brain Barrier Penetration, tumor Targeting And Cancer Metastasis Treatment, Methods Of Production And Uses Thereof
A formulation of mesoporous silica nanoparticles with blood brain barrier targeting moieties on their surface as a delivery system for tumor /CNS disease treatment.
US-11413243- Fusogenic Compounds for Delivery Of Biologically Active Molecules
This invention describes the use of fusogenic compounds used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics.
US-11413348- Low Molecular Weight Cationic Lipids for Oligonucleotide Delivery
A description of novel cationic lipids that can be used in combination with other lipid components to form lipid nanoparticles with oligonucleotides. The invention claims enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. In vivo delivery of siRNA is given as an example usage of this technology.
US-11413281-Ternary Conjugate of Antitumor Drug, And Synthesis and Application
A targeted delivery system for a hydrophobic antitumor drug, comprised of conjugates of E-selectin polypeptide ligand-polyethylene glycol-antitumor drug. The conjugates can actively target at vessels of a tumor site by the E-selectin peptide ligand and can also self-assemble into nanoparticles in an aqueous solution, so as to be passively targeted at the tumor site by EPR effect.
US-11413253-Nanoparticle Delivery Systems
Nanoparticle compositions described herein comprise combinations of prodrugs of therapeutic agents.
US-111413252-Membrane Lipid Coated Viral Nanoparticles and Method Of Use
Disclosed is a nanoparticle comprising an inner core comprising a virus; and an outer surface comprising a cellular membrane derived from a cell. An example is given with the virus is an oncolytic virus and cellular membrane being derived from red blood cells.
US-11406706-Lipid Nanoparticle Vaccine Adjuvants and Antigen Delivery Systems
Formulation method and use of novel lipid nanoparticle (LNP) formulations, containing cationic lipids, for use as vaccine adjuvants and/or as antigen delivery systems of vaccine antigens.
US-11406597-Fusogenic Liposome-coated Porous Silicon Nanoparticles
Description of a delivery system made up of liposome-coated porous silicon nanoparticles with anionic payloads such as small molecules, dyes and nucleic acids. Further surface modifications for targeted delivery of the encapsulated payload.
US-11406604- Nano capsules and Method for Manufacturing Thereof
A method for manufacturing supported lipid bilayer on a porous silica nanoparticle. Lipids include DOTAP, cholesterol and a third distinct lipid. Incorporation of alginate is also described for further functionality of the platform.
US-11400109- Subcutaneous Delivery of Messenger RNA
The present invention provides, among other things, methods of formulating nucleic acid-containing nanoparticles with an enzyme to afford efficient delivery of payload via subcutaneous administration for delivery to the liver or other tissues.
US-11400187-Therapeutic Nanoparticles for Treating Vascular Diseases
Description of nano and microparticles for treatment of restenosis or blood clots. Targeting moieties can be incorporated into the formulation along with magnetic particles to target the particles by a magnetic field. The particle formulations can be incorporated into medical device coatings or administered systemically or locally.
US-11400085-Method for Preparing Pharmaceutical Composition for Preventing Or Treating Cognitive Impairment-related Disease And Pharmaceutical Composition For Preventing Or Treating Cognitive Impairment-related Disease Prepared By The Same
Description of a formulation for preventing cognitive impairment in which donepezil is encapsulated in a biodegradable polymer in a matrix morphology. The extended-release formulation allows for monthly dosing instead of daily treatments.
Bio/Medical
US- 11472856- Methods and Compositions for Promoting Immune Cell Function
Describes the use of nanoparticles loaded with IL-15 to conserve immune cell function after freezing and thawing an immune cell.
US- 11472898- Method for Surface Modification Of Nanoparticles
A method for surface modification of nanoparticles involving removal of ligands from the surface of the nanoparticles and mixing new ligands with the ligand-free nanoparticles to form modified nanoparticles.
US- 11471335-Gel-within-gel Wound Dressing
Wound dressings that include a crosslinked hydrogel matrix and a plurality of porous absorbent microspheres encapsulated in the crosslinked matrix that can be used in treating chronic wounds, burn wounds, and can promote autolytic debridement.
US- 11471565-Engineered Tissue Constructs
Description of using nano and/or microparticles to promote cell aggregation in order to act as a bulking agent, enhance mechanical properties as well as deliver bioactive agents within the system.
US- 11458200-Constructs, Agents, And Methods for Facilitated Ablation Of Cardiac Tissue
Description of the use of metallic nanoparticles excited by radiofrequency energy to ablate tissues to which the nanoparticles were magnetically guided.
US- 11452777-Method for Synthesizing a New Ferrihydrite Nano-photosensitizer And Its Antibacterial And Anticancer Use
Description of a method for synthesizing a new ferrihydrite nano-photosensitizer formulation made up of PEG-modified ferrihydrite nanoparticles. These particles can be reduced by blue light causing the release Fe2+, and then produce OH- in the cell, which induces cell oxidative damage, for anticancer and antibacterial treatments.
US- 11446413-Attenuation of Encrustation of Medical Devices Using Coatings Of Inorganic Fullerene-like Nanoparticles
Use of negatively charged nanoparticles to coat and reduce the encrustation of catheters.
US- 11447733-Transparent Disc-shaped Microparticles Coated with Polydopamine
The present invention relates to transparent disc-shaped microparticles having polydopamine-modified surfaces for use in cell cultures resulting in improved cell adhesive properties allowing for inverted microscope observations.
US- 11439731-Artificial Tissue Progenitor and Method For Preparing The Same
Describes the use of microencapsulation of living cells placed on a 3D printed support for artificial tissue progenitor systems such as artificial lumen for implants or a lumen model.
US- 11439688-Synthetic Platelets
A synthetic platelet with a biocompatible flexible nanoparticle with site targeted peptides conjugated to the surface. The nanoparticle is loaded with a therapeutic agent. The synthetic platelet adheres to the site and thus promotes delivery of the therapeutic agent while the active is released in the presence of a site-relevant enzyme.
US-11433149-Microsphere and Preparation Method Thereof
Provided is a microsphere including a glass sphere core containing nuclides for targeted radiation therapy.
US-11420986-Functionalized Mesoporous Silica Via an Aminosilane Surfactant Ion Exchange Reaction: Controlled Scaffold Design And Nitric Oxide Release
A formulation method for the preparation of nitric oxide-releasing mesoporous silica nanoparticles. The release rate of the NO from the particles can be optimized for maximum efficacy.
US-11419952-Functionalized Nanoparticles and Methods Of Making And Using Same
Methods to modify the surface of nanoparticles are given. This allows for incorporation of several properties into a single nanoparticle formulation such as, fluorescence detection, specific cell targeting, radioisotope chelating/ labeling, ratiometric pH sensing, and drug delivery, while maintaining a size of 10 nm.
US-11419892-Antimicrobial Platelet-like Particles
Description of production and use of platelet-like particles with antimicrobial metallic nanoparticles with a fibrin targeting moiety. The particles are useful to stop bleeding and to promote wound healing while suppressing bacterial growth/infection.
US-11413319-Microencapsulation of Bacteriophages and Related Products
A polymer encapsulated bacteriophage formulation is given.
US-11400111-Method for Producing Gum Arabic Encapsulated Metal Nanoparticles
Description of stabilized metal nanoparticles in gum arabic for dental and gingival preventative treatments.
Consumer Products/ Cosmetics
US- 11471397- Process for The Preparation Of Microcapsules
A new process of preparing microcapsules with application in perfuming compositions and consumer products in the form of home care or personal care products.
US- 11471386- Non-spherical Microcapsule
Disclosed is a non-spherical microcapsule comprising a core comprising a benefit agent, and a shell comprising nanoparticles having a diameter of 10 to 300 nm and polyurea. Uses in home and personal care products are described.
US- 11464811- Microcapsules Loaded with Probiotics and Production Thereof
A production method of microencapsulated probiotics with chitosan-alginate polymers. Uses in food, agriculture and cosmetics are described.
US- 11452741-Compositions and Methods For Treating Transient Biofilms
Disinfecting compositions containing hypochlorous acid and acetic acid are useful for treating transient biofilms in or on tissue without harming the natural flora of the tissue. Compositions may be provided in mouthwash form, spray form, gel form, cream form, dentifrice form, and may include nanoparticle encapsulated molecules for controlled release.
US- 11439979- Method of Making Colloidal Selenium Nanoparticles
Provided is a method of making colloidal selenium nanoparticles. The method has advantages of simplicity, safety, time-effectiveness, cost-effectiveness, high yield, and eco-friendliness.
US- 11433008- Composition Comprising Photonic Particles, At Least One Absorber And At Least One Surfactant
Description of a photoprotective cosmetic composition using microparticles to diffract/reflect and absorb various wavelengths of light.
US- 11413237- Skin Penetration Enhancing Composition and Use Thereof In Preparation Of Skin Delivery Formulation
Description of a skin penetration enhancing composition and a use thereof. The formulation comprises sponge spicules and nanoparticles which contain and release the cosmetic or active ingredient.
US- 11401485- Microcapsule System for Polysensory Olfactory Effects I
A multi-shell encapsulation system with an outer and inner microcapsule shell containing two distinct fragrances.
Observations/Thoughts/Trends/Musings
Greetings, Reader. If you’ve made it this far again, I applaud you. You may notice the article is longer than those previous. Over 250 patent abstracts were reviewed for this quarter. That larger number (I usually go through about 150 abstracts) may be due to the upgraded search engine available on the public US Patent website. The engine offers more options for searching and displaying results. I encourage you to take a look at the website yourself and test it out. It’s a fun way to spend a weekend…
Beyond the higher number of patents observed, the same trends seen previously are seen here. Pharmaceutical applications dominate the patents but there are many biological and medical applications that are distinct from traditional pharma applications represented. Agricultural patents were not very prevalent this time and slightly more patents in the consumer products and cosmetics area were observed. Whether or not these findings are related to algorithm changes in the search engine remains to be seen…
Until next quarter, happy holidays.
Ken
