Patent Watch: March 2024 - May 2024
This article summarizes selected patents in the area of controlled release or delivery that were issued from March 1, 2024 through May 31, 2024. Greater detail on each of these patents is given on the U.S. patent website Patent Public Search | USPTO
General/Industrial Applications
US- 11993743- Double-chamber Microcapsule for Drilling Fluid And Self-reversing Reversible Water-in-oil Drilling Fluid And Preparation Method Thereof
A double-chamber microcapsule wherein the wall is a thermo-sensitive polymer; the capsule core is a pH responsive polymer encapsulating the content of a first chamber; the content of the first chamber is different from the content of the second chamber, each is selected from a solid acid or a solid alkali.
US- 11980863- Heat-expandable Microspheres and Application Thereof
Heat-expandable microspheres containing a thermoplastic resin shell and a thermally vaporizable blowing agent encapsulated therein. Also disclosed are hollow resin particles manufactured by expanding the heat-expandable microspheres.
US- 11964249- Milk Protein Concentrate-based Microencapsulation Wall Material and Microcapsules
Liquid or solid microcapsules are prepared by performing cation exchange treatment on milk protein concentrates, as a wall material. The prepared microcapsules have good physical and chemical stability during storage, and are suitable for protecting active functional factors and to be applied in the fields of food, medicine, health care products, cosmetics, etc.
US- 11951449- Method for Preparing Organic-inorganic Hybrid Microcapsule
A method for preparing a biodegradable and eco-friendly organic-inorganic hybrid microcapsule by using a pickering emulsion method with a specific outer wall reinforcing material, a reactive material, and inorganic nanoparticles, and allowing polymerization of the outer wall reinforcing material and the reactive material to proceed at the interface. The microcapsule can stably support an active ingredient and then express its activity by pressure, and gradually release the active ingredient at room temperature.
US- 11952492- Biodegradable, Controlled Release Microcapsules
Controlled release biodegrading microcapsules comprising polypeptide chains.
US- 11945946- Polyurea and Poly(beta-amino Ester) Capsules with Enhanced Degradability
Microcapsules for encapsulating oily core materials with a shell made up of hybrid polyurea and poly(beta-amino esters) (PU/PBAE) are described.
US- 11931711- Microcapsule Clusters
The present invention teaches a composition and process for irreversibly agglomerated charge stable core shell microcapsules. The capsules of the invention adhere better to surfaces, are more stable and are useful for delivery of benefit agents.
Agriculture
US- 11965196- Enzymatic Preparation Method of Inclusion Complexes of Tributyrin
The disclosure combines enzymatic synthesis of cyclodextrin and inclusion of tributyrin with cyclodextrin followed by spray drying. The effect of the finally obtained tributyrin powder is much better than that of single inclusion of tributyrin with cyclodextrin when used as a livestock and/or poultry supplement.
Diagnostic/Sensing
US- 11992358- Multimodality Anthropomorphic Phantom Apparatus
Description of contrast system for imaging that utilizes several components including glass microspheres.
US- 11970620- Method for Preparing High Sensitivity Temperature Sensitive Reversible Color-changing Microcapsule
The disclosure relates to a method for preparing a high sensitivity temperature sensitive reversible color-changing microcapsule made using a solvent evaporation method.
US- 11959912- Fluorescence Immunochromatographic Detection Card and A Preparation Method Therefor And Use Thereof
The fluorescence immunochromatographic detection card comprises two treatment liquids and a detection card. The treatment liquid A contains an antibody 15C4 that is coupled with a fluorescent microsphere. The treatment liquid B contains an antibody 13G12 that is coupled with biotin. The fluorescence immunochromatographic detection card has characteristics such as high sensitivity, high specificity, and high stability, and can be applied to the rapid detection of disease markers.
US- 11921109- Microfluidic System and Method For Real-time Measurement Of Antibody-antigen Binding And Analyte Detection
Microfluidic devices for use with reagents bound to microspheres for determination of the concentration of an analyte in a liquid sample are provided.
US- 11918315- Determination of Structure and Traversal Of Occlusions Using Magnetic Particles
This disclosure generally relates to systems and methods for facilitating determination of morphology, structure and/or penetrating channels of occlusions (e.g., clots, fluid obstructions, tumors, chronic total occlusions) involving magnetic particles controlled by an external magnetic control system.
Pharma
US- 11992559- Microsphere Formulations Comprising Lurasidone and Methods for Making And Using The Same
Extended-release microsphere formulations comprising lurasidone are provided in which the lurasidone is released in vivo in humans over a period of about 30 days.
US- 11981714- CCR5 And CD4 SiRNA-targeted Phospholipid Nanosomes Therapeutics for Treatment of HIV-1 and Other Diseases
The present invention pertains to the nanoencapsulation of siRNA and other biologics in phospholipid nanosomes for the improved delivery of siRNA and other biologics to targeted diseased human or animal organs and human or animal cells and apparatus and methods for making the same.
US- 11951104- Aripiprazole Sustained-release Microsphere and Preparation Method Therefor
The present invention provides an aripiprazole sustained-release microsphere containing polylactide-glycolide. The microsphere contains reticular micropores filled with aripiprazole comprising 65-80% of the total weight of the microsphere.
US- 11951152- Microparticle Compositions for Controlled Delivery Of Telmisartan And Actinomycin D
Description of microparticle compositions for the controlled delivery of telmisartan and actinomycin D.
US- 11925708- Method for Making Modified Polyvinyl Alcohol Embolic Microsphere
The invention provides a method of generating polyvinyl alcohol embolic microspheres. The invention aims at improving the drug loading rate and drug loading speed of the microspheres.
Bio
US- 11958947- Core-shell Microcapsules, Manufacturing Processes and Uses
Core-shell microcapsules useful for compartmentalizing biological molecules in solution.
US- 11944655- Probiotic Microcapsule
The microcapsule comprises a core in the form of a lipid sphere coated by a protein film, wherein the lipid sphere comprises sporulated microorganisms and at least one lipid wall material, and the protein film is a mix of carbohydrate, protein material and water.
US- 11946073- Method for Non-enzymatic 3D Culture And amplification Of Mesenchymal Stem Cells
A method for non-enzymatic 3D culture and amplification of mesenchymal stem cells (MSCs) using PLGA porous microspheres as a growth scaffold for MSCs which can be later separated from the microspheres utilizing the PLGA-PEG-PLGA coating on the microspheres and centrifugation and eliminating the need for enzymolysis thus increasing the efficiency of propagation of the stem cells.
US- 11931461- Microparticles Containing Moxidectin, And Preparation Method Therefor
The present invention relates to microparticles comprising moxidectin and a biodegradable polymer, for extended release and protection against heartworm disease for 3 to 6 months.
US- 11921110- Method for Producing An Array Of Planar Microparticles With Surface Molecular Multiplexing, Resulting Array And Use Thereof
A method for controlled production of an array of planar microparticles multiplexed with molecules, as molecular sensors and/or actuators Different molecular elements are multiplexed on the surface of each particle while they are supported on a substrate by means of a structural foot engraved below the particle. These microparticles can be released mechanically from the support on which they are produced using a controlled mechanical rupture method which is not chemically aggressive and therefore does not affect the molecules previously printed on the surface.
Consumer Products/ Cosmetics
US- 11986790- Method for Preparing Microcapsules
A method for preparing surface modified microcapsules that increase adhesion of fragrance capsules to fabric fibers. Capsules are generated by preparing a pickering emulsion using inorganic nanoparticles and acrylic monomers comprising biodegradable ester groups, followed by polymerization of monomers to generate capsule walls.
US- 11981830- Aqueous Dispersion of Polymer Particles, Microspheres, And Polysiloxane Particles
The present invention relates to a paint composition comprising an aqueous dispersion of polymer particles of various sizes, a rheology modifier, an opacifying white pigment, and a low Tg polyurethane thus imparting burnish resistance.
US- 11964043- Method of Emulsification Using Core-corona Type Microparticles
A method of emulsification of an oil phase in an aqueous continuous phase, by dispersing core-corona microparticles into the aqueous phase, adding the oil phase, and applying shearing force for a time sufficient to emulsify the resulting mixture. The core-corona microparticles are obtained by radical co-polymerization of a polyethylene oxide macromonomer with at least one hydrophobic acrylate monomer and at least one hydrophobic acrylamide monomer. This eliminates the use of surfactants in cosmetic formulations
US- 11958030- Coacervate Core-shell Microcapsules
The present invention relates to plant-based coacervate core-shell microcapsules, wherein the shell comprises a plant protein extract, as well as methods and uses of the same.
Observations/Thoughts/Trends/Musings
Interestingly enough, the number of patents in the field of encapsulation and controlled release for this quarter is lower than usual. Equally interesting is the number of patents in pharmaceuticals. While this usually is the predominate area of intellectual property protection observed, this is not the case as many other non-pharma applications had good representation in patents granted.
Hope to see you all in Bologna. The annual meeting will be jam-packed with people, interesting sessions, great social/network events, and posters.
Until then!
K
