Scientifically Speaking
Date:
Andi Dian Permana1, Alejandro J. Paredes2, Fabiana Volpe-Zanutto2,3, Muh. Nur Amir4, Ismail Ismail5, Muh. Akbar Bahar4, Sumarheni6, Santiago Daniel Palma7, Ryan F. Donnelly2*…
IntroductionNowadays, most of the currently available ocular drugs are administered topically through eye drops,1 but their residence time in the eye is short, about 2 min…
IntroductionCorticosteroids such as dexamethasone are the first line of treatment for noninfectious posterior uveitis and are also routinely used for the treatment of age-related macular degeneration (AMD) (Figure 1…
Macromolecular prodrugs (MP), or polymer–drug conjugates, are successful tools of drug delivery investigated broadly toward optimization of pharmacokinetics of drugs.1 Specific advantage is gained when, for example, the polymer increases solubility of the drug or aids in localizing an enhanced…
Introduction
Ile-Pro-Pro (IPP) is a bioactive peptide found in bovine milk when casein is hydrolyzed by gastrointestinal enzymes. It has an angiotensin-converting enzyme inhibitory potency of 5µM with the potential to reduce blood pressure, if orally administered.1 Although IPP is stable in…
Introduction
Figure 1. Mechanistic and kinetic analysis of the model system.Food can significantly impact the bioavailability of oral drugs through multiple mechanisms including enhancement of solubility and dissolution kinetics, enhancement of permeation through the intestinal mucosa, and so on.…
