Scientifically Speaking
Introduction
Therapeutically relevant proteins such as antibodies, growth factors, and enzymes play an increasing role in the treatment of malignant and autoimmune diseases. However, they often suffer from insufficient stability and poor bioavailability. A suitable method to increase protein…
Introduction
Long-acting injectable (LAI) (pro)drug nano-/microsuspensions—aqueous dispersions of pure (pro)drug nano-/microcrystals—have shown potential as a drug delivery strategy over the past decade and are now recognized as an attractive formulation option for poorly water-soluble drug…
Introduction
In non-small cell lung cancer (NSCLC), the level of oxygenation surrounding the cancerous cells is low compared with normal tissue owing to the rapid growth of the tumor cells. The decreased blood circulation results in development of pockets of lower oxygen levels, resulting in…
Introduction
Fibrin hydrogels are protein-based scaffolds frequently used in tissue engineering for delivery of bioactive payloads (e.g., growth factors). Conventional fibrin scaffolds enable very limited spatial and temporal control of payload release, especially after implantation. This is…
Introduction
Figure 1. (A) Schematic of a human knee joint showing the development of fibrotic scar tissue and an arthrofibrotic joint post injury or surgery. (B) Representative images of normal healthy goat knee (bottom left) and arthrofibrotic goat knee (bottom right). Images courtesy of David…
Introduction
Electrospinning is an electrostatic fiber fabrication technique producing homogeneous fibers in the nanometer range. The process involves dropping a polymer solution in an electric field in such a way that the electric forces overcome the polymer solution surface tension and the drop…
