Scientifically Speaking
Macromolecular prodrugs (MP), or polymer–drug conjugates, are successful tools of drug delivery investigated broadly toward optimization of pharmacokinetics of drugs.1 Specific advantage is gained when, for example, the polymer increases solubility of the drug or aids in localizing an enhanced…
Introduction
Overexpression of cyclooxegenase-2 (COX-2) is a hallmark of inflammation and an early event in carcinogenesis and cancer progression.1,2 Because COX-2 is expressed in virtually all solid tumors, it represents an ideal biomarker with broad impact for the early clinical detection of…
Introduction
Figure 1. Mechanistic and kinetic analysis of the model system.Food can significantly impact the bioavailability of oral drugs through multiple mechanisms including enhancement of solubility and dissolution kinetics, enhancement of permeation through the intestinal mucosa, and so on.…
Introduction
Therapeutically relevant proteins such as antibodies, growth factors, and enzymes play an increasing role in the treatment of malignant and autoimmune diseases. However, they often suffer from insufficient stability and poor bioavailability. A suitable method to increase protein…
Introduction
Long-acting injectable (LAI) (pro)drug nano-/microsuspensions—aqueous dispersions of pure (pro)drug nano-/microcrystals—have shown potential as a drug delivery strategy over the past decade and are now recognized as an attractive formulation option for poorly water-soluble drug…
Introduction
Figure 1. (A) Schematic of a human knee joint showing the development of fibrotic scar tissue and an arthrofibrotic joint post injury or surgery. (B) Representative images of normal healthy goat knee (bottom left) and arthrofibrotic goat knee (bottom right). Images courtesy of David…
