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Dynamic In Vitro Characterization of Micellar Structures in the GI Tract During Food Digestion Using SANS

Authors:

Oljora Rezhdo, Selena Di Maio, Peisi Le, Kenneth Littrell, Sow-Hsin Chen, Rebecca Carrier

Introduction Figure 1. Mechanistic and kinetic analysis of the model system.Food can significantly impact the bioavailability of oral drugs through multiple mechanisms including enhancement of solubility and dissolution kinetics, enhancement of permeation through the intestinal mucosa, and so on.…

Celebrating 20 Years of Excellent Research and Translation

Authors:

Dan Peer

The 10th annual meeting of the CRS Israeli Local Chapter (ICRS), “20 Years of Excellent Research and Translation,” was held in Maalot, in the north of Israel, on September From left to right: Yechezkel (Chezy) Barenholz (Hebrew University), Phil Low (Purdue University), Alan Packard (Harvard…

NZCRS Publication Ethics and Manuscript Writing Workshop

Authors:

Zimei Wu, Darren Svirskis, Dedeepya Uppalapati

David Grainger presents on how to write a good research paper.In June 2016, the New Zealand Local Chapter of the Controlled Release Society (CRS) hosted David W. Grainger (University of Utah, U.S.A.) for an educational workshop at the Faculty of Medical and Health Sciences, University of Auckland.…

My Last “From the Editor”

Authors:

Yvonne Perrie

Dear Reader, Welcome again to the CRS Newsletter, which is packed with news and updates on science and our society; we have an update from the New Zealand Chapter and on the 2017 CRS Annual Meeting in Boston—this looks to be a very exciting meeting. We also have an interesting interview with Terry…

Questioning the Rate-Limiting Drug Release and Absorption Mechanisms from an Intramuscular Long-Acting Injectable Prodrug Nano-/Microsuspension: The Effect of Local Macrophage Depletion

Authors:

Nicolas Darville, Marjolein van Heerden, Stefaan Rossenu, Guy Van den Mooter, Sandra De Jonghe, An Vermeulena

Introduction Long-acting injectable (LAI) (pro)drug nano-/microsuspensions—aqueous dispersions of pure (pro)drug nano-/microcrystals—have shown potential as a drug delivery strategy over the past decade and are now recognized as an attractive formulation option for poorly water-soluble drug…

Boston: City of Champions

Authors:

Medha Joshi

The 44th CRS annual meeting was held in Boston, Massachusetts, the “City of Champions.” Like the five-time Super Bowl champions, the New England Patriots, Boston has always been a champion of pharmaceutical innovation. In fact, Bloomberg Business ranked Massachusetts the #1 state for innovation…