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Introduction
Long-acting injectable (LAI) (pro)drug nano-/microsuspensions—aqueous dispersions of pure (pro)drug nano-/microcrystals—have shown potential as a drug delivery strategy over the past decade and are now recognized as an attractive formulation option for poorly water-soluble drug…
Terry in her office with a backdrop of research books.Prof. Theresa Mary Allen, a veteran in the drug-delivery field for over 30 years, is a pioneer in the field of long-circulating liposomes and ligand-targeted nanomedicines for anticancer drugs and gene medicines. She has over 200 peer-reviewed…
Introduction
Figure 1. (A) Schematic of a human knee joint showing the development of fibrotic scar tissue and an arthrofibrotic joint post injury or surgery. (B) Representative images of normal healthy goat knee (bottom left) and arthrofibrotic goat knee (bottom right). Images courtesy of David…
It’s springtime in the northern hemisphere, with the days getting longer and warmer, and the flowers blooming. Even though I now live in Texas, I’m reminded of my many walks around Boston and Cambridge in the spring. I lived in the Boston area for twenty years and developed a tradition of taking a…
Introduction
In non-small cell lung cancer (NSCLC), the level of oxygenation surrounding the cancerous cells is low compared with normal tissue owing to the rapid growth of the tumor cells. The decreased blood circulation results in development of pockets of lower oxygen levels, resulting in…
Introduction
Fibrin hydrogels are protein-based scaffolds frequently used in tissue engineering for delivery of bioactive payloads (e.g., growth factors). Conventional fibrin scaffolds enable very limited spatial and temporal control of payload release, especially after implantation. This is…
